Significance of Radiofrequency Ablation for Unresectable Colorectal Cancer With Liver Metastases

被引：14

作者：

Tago, Tomoya ^{[1
]}

Katsumata, Kenji ^{[1
]}

Udou, Ryutaro ^{[1
]}

Kasahara, Kenta ^{[1
]}

Mazaki, Junichi ^{[1
]}

Kuwabara, Hiroshi ^{[1
]}

Enomoto, Masanobu ^{[1
]}

Ishizaki, Tetsuo ^{[1
]}

Nagakawa, Yuichi ^{[1
]}

Sugimoto, Katsutoshi ^{[2
]}

Itoi, Takao ^{[2
]}

Tsuchida, Akihiko ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Gastrointestinal & Pediat Surg, Tokyo, Japan

[2] Tokyo Med Univ, Dept Gastroenterol & Hepatol, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2021年 / 41卷 / 11期

关键词：

Colorectal cancer; liver metastasis; radiofrequency ablation; resection; chemotherapy; prognosis; THERMAL ABLATION; HEPATIC RESECTION; SURVIVAL;

D O I：

10.21873/anticanres.15367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

prognosis of patients who received radiofrequency ablation (RFA) for liver metastases of unresectable colorectal cancer (CRC). Patients and Methods: We retrospectively compared 147 patients treated for CRC liver metastases, who underwent RFA (n=26), resection (n=92), and chemotherapy (n=29) between 2001 and 2021. Results: RFA and chemotherapy were performed for unresectable or non-operable cases, and resection was performed for suitable cases. The median overall survival (OS) was 44.9, 49.5, and 11.6 months for patients who underwent RFA, resection, and chemotherapy, respectively. RFA led to a significantly shorter OS compared to resection (p=0.027) but to a longer OS compared to chemotherapy (p=0.003). The 5-year survival rates were 34.6% and 42.4% for patients who underwent RFA and resection, respectively (p=0.508). Conclusion: RFA has the potential to achieve long

引用

页码：5539 / 5547

页数：9

共 25 条

[1] Patients With Initially Unresectable Colorectal Liver Metastases: Is There a Possibility of Cure? [J].

Adam, Rene ;

Wicherts, Dennis A. ;

de Haas, Robbert J. ;

Ciacio, Oriana ;

Levi, Francis ;

Paule, Bernard ;

Ducreux, Michel ;

Azoulay, Daniel ;

Bismuth, Henri ;

Castaing, Denis .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (11) :1829-1835

[2] Solitary colorectal liver metastasis - Resection determines outcome [J].

Aloia, TA ;

Vauthey, JN ;

Loyer, EM ;

Ribero, D ;

Pawlik, TM ;

Wei, SH ;

Curley, SA ;

Zorzi, D ;

Abdalla, EK .

ARCHIVES OF SURGERY, 2006, 141 (05) :460-466

[3] Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer [J].

Amado, Rafael G. ;

Wolf, Michael ;

Peeters, Marc ;

Van Cutsem, Eric ;

Siena, Salvatore ;

Freeman, Daniel J. ;

Juan, Todd ;

Sikorski, Robert ;

Suggs, Sid ;

Radinsky, Robert ;

Patterson, Scott D. ;

Chang, David D. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1626-1634

[4] Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver: A prospective study [J].

Berber, E ;

Pelley, R ;

Siperstein, AE .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (07) :1358-1364

[5] Resection Versus Laparoscopic Radiofrequency Thermal Ablation Of Solitary Colorectal Liver Metastasis [J].

Berber, Eren ;

Tsinberg, Michael ;

Tellioglu, Gurkan ;

Simpfendorfer, Conrad H. ;

Siperstein, Allan E. .

JOURNAL OF GASTROINTESTINAL SURGERY, 2008, 12 (11) :1967-1972

[6] Immediate and Long-term Results of Radiofrequency Ablation for Colorectal Liver Metastases [J].

Cirimbei, Ciprian ;

Rotaru, Vlad ;

Chitoran, Elena ;

Pavaleanu, Oana ;

Cirimbei, Simona Elena .

ANTICANCER RESEARCH, 2017, 37 (11) :6489-6494

[7] Neoadjuvant treatment of unresectable colorectal liver metastases:: correlation between tumour response and resection rates [J].

Folprecht, G ;

Grothey, A ;

Alberts, S ;

Raab, HR ;

Köhne, CH .

ANNALS OF ONCOLOGY, 2005, 16 (08) :1311-1319

[8] Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment [J].

Grothey, A ;

Sargent, D ;

Goldberg, RM ;

Schmoll, HJ .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (07) :1209-1214

[9] Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE) [J].

Grothey, Axel ;

Sugrue, Mary M. ;

Purdie, David M. ;

Dong, Wei ;

Sargent, Daniel ;

Hedrick, Eric ;

Kozloff, Mark .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (33) :5326-5334

[10] Survival after Hepatic Resection for Metastatic Colorectal Cancer: Trends in Outcomes for 1,600 Patients during Two Decades at a Single Institution [J].

House, Michael G. ;

Ito, Hiromichi ;

Gonen, Mithat ;

Fong, Yuman ;

Allen, Peter J. ;

DeMatteo, Ronald P. ;

Brennan, Murray F. ;

Blumgart, Leslie H. ;

Jarnagin, William R. ;

D'Angelica, Michael I. .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2010, 210 (05) :744-752

← 1 2 3 →