Significance of Radiofrequency Ablation for Unresectable Colorectal Cancer With Liver Metastases

被引：10
作者：
Tago, Tomoya [1 ]
Katsumata, Kenji [1 ]
Udou, Ryutaro [1 ]
Kasahara, Kenta [1 ]
Mazaki, Junichi [1 ]
Kuwabara, Hiroshi [1 ]
Enomoto, Masanobu [1 ]
Ishizaki, Tetsuo [1 ]
Nagakawa, Yuichi [1 ]
Sugimoto, Katsutoshi [2 ]
Itoi, Takao [2 ]
Tsuchida, Akihiko [1 ]
机构：
[1] Tokyo Med Univ, Dept Gastrointestinal & Pediat Surg, Tokyo, Japan
[2] Tokyo Med Univ, Dept Gastroenterol & Hepatol, Tokyo, Japan
来源：
ANTICANCER RESEARCH | 2021年 / 41卷 / 11期
关键词：
Colorectal cancer; liver metastasis; radiofrequency ablation; resection; chemotherapy; prognosis; THERMAL ABLATION; HEPATIC RESECTION; SURVIVAL;
D O I：
10.21873/anticanres.15367
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
prognosis of patients who received radiofrequency ablation (RFA) for liver metastases of unresectable colorectal cancer (CRC). Patients and Methods: We retrospectively compared 147 patients treated for CRC liver metastases, who underwent RFA (n=26), resection (n=92), and chemotherapy (n=29) between 2001 and 2021. Results: RFA and chemotherapy were performed for unresectable or non-operable cases, and resection was performed for suitable cases. The median overall survival (OS) was 44.9, 49.5, and 11.6 months for patients who underwent RFA, resection, and chemotherapy, respectively. RFA led to a significantly shorter OS compared to resection (p=0.027) but to a longer OS compared to chemotherapy (p=0.003). The 5-year survival rates were 34.6% and 42.4% for patients who underwent RFA and resection, respectively (p=0.508). Conclusion: RFA has the potential to achieve long
引用
收藏
页码：5539 / 5547
页数：9
相关论文
共 25 条
  • [1] Patients With Initially Unresectable Colorectal Liver Metastases: Is There a Possibility of Cure?
    Adam, Rene
    Wicherts, Dennis A.
    de Haas, Robbert J.
    Ciacio, Oriana
    Levi, Francis
    Paule, Bernard
    Ducreux, Michel
    Azoulay, Daniel
    Bismuth, Henri
    Castaing, Denis
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (11) : 1829 - 1835
  • [2] Solitary colorectal liver metastasis - Resection determines outcome
    Aloia, TA
    Vauthey, JN
    Loyer, EM
    Ribero, D
    Pawlik, TM
    Wei, SH
    Curley, SA
    Zorzi, D
    Abdalla, EK
    [J]. ARCHIVES OF SURGERY, 2006, 141 (05) : 460 - 466
  • [3] Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    Amado, Rafael G.
    Wolf, Michael
    Peeters, Marc
    Van Cutsem, Eric
    Siena, Salvatore
    Freeman, Daniel J.
    Juan, Todd
    Sikorski, Robert
    Suggs, Sid
    Radinsky, Robert
    Patterson, Scott D.
    Chang, David D.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) : 1626 - 1634
  • [4] Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver: A prospective study
    Berber, E
    Pelley, R
    Siperstein, AE
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (07) : 1358 - 1364
  • [5] Resection Versus Laparoscopic Radiofrequency Thermal Ablation Of Solitary Colorectal Liver Metastasis
    Berber, Eren
    Tsinberg, Michael
    Tellioglu, Gurkan
    Simpfendorfer, Conrad H.
    Siperstein, Allan E.
    [J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2008, 12 (11) : 1967 - 1972
  • [6] Immediate and Long-term Results of Radiofrequency Ablation for Colorectal Liver Metastases
    Cirimbei, Ciprian
    Rotaru, Vlad
    Chitoran, Elena
    Pavaleanu, Oana
    Cirimbei, Simona Elena
    [J]. ANTICANCER RESEARCH, 2017, 37 (11) : 6489 - 6494
  • [7] Neoadjuvant treatment of unresectable colorectal liver metastases:: correlation between tumour response and resection rates
    Folprecht, G
    Grothey, A
    Alberts, S
    Raab, HR
    Köhne, CH
    [J]. ANNALS OF ONCOLOGY, 2005, 16 (08) : 1311 - 1319
  • [8] Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    Grothey, A
    Sargent, D
    Goldberg, RM
    Schmoll, HJ
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (07) : 1209 - 1214
  • [9] Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)
    Grothey, Axel
    Sugrue, Mary M.
    Purdie, David M.
    Dong, Wei
    Sargent, Daniel
    Hedrick, Eric
    Kozloff, Mark
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (33) : 5326 - 5334
  • [10] Survival after Hepatic Resection for Metastatic Colorectal Cancer: Trends in Outcomes for 1,600 Patients during Two Decades at a Single Institution
    House, Michael G.
    Ito, Hiromichi
    Gonen, Mithat
    Fong, Yuman
    Allen, Peter J.
    DeMatteo, Ronald P.
    Brennan, Murray F.
    Blumgart, Leslie H.
    Jarnagin, William R.
    D'Angelica, Michael I.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2010, 210 (05) : 744 - 752
123