The aim of this study was to evaluate the effect of 1,200 mu g/kg of Aflatoxin B-1 (AF(B1)), Aflatoxin B-2 (AF(B2)) and three mycotoxins adsorbents on growth performance, antibody titers to Newcastle, blood chemistry and histopathological lesions in broilers. One hundred ninety two one-day old chickens were randomly divided into 4 treatments and 3 replicates of 16 chickens, in a 42-day experiment. Treatments evaluated: T1 = basal diet; T2 = basal diet with 1,200 mu g/kg of AF(B1) and AF(B2); T3 = basal diet with 1,200 mu g/kg of AF(B1) and AF(B2) plus adsorbent (A); T4 = basal diet with 1200 mu g/kg of AF(B1) and AF(B2) plus adsorbent (B). The results indicate that the chickens eating the adsorbent (A) and 1200 mu g/kg of AF(B1) and AF(B2), improved their feed conversion (FC), increased its antibody titers to Newcastle (ATN) at 21 and 42 days, decreased the aspartate transaminase (AST) at 21 days and it increased its albumin (A) and total protein (TP) at 21 and 42 days. Uric acid (UA) decreased within 42 days. The histopathological lesions were similar in the chickens, independently of treatment. In conclusion, the aflatoxins B-1 and B-2 at a concentration of 1,200 mu g/kg and the adsorbent (A) for 42 days can reduce FC, increase ATN, reduce AST, reduce the UA and raise the A and TP, however this was not the case for adsorbent (B) when is combined with the aflatoxins in the level previously mentioned.