SERS Quantification and Characterization of Proteins and Other Biomolecules

被引：129

作者：

Feliu, Neus ^{[1
,2
]}

Hassan, Moustapha ^{[2
]}

Garcia Rico, Eduardo ^{[3
,4
,5
,6
]}

Cui, Daxiang ^{[7
]}

Parak, Wolfgang ^{[1
,7
,8
]}

Alvarez-Puebla, Ramon ^{[9
,10
]}

机构：

[1] Philipps Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany

[2] Karolinska Inst, Dept Lab Med, Expt Canc Med, S-14186 Stockholm, Sweden

[3] Fdn Invest HM Hosp, San Bernardo 101, Madrid 28015, Spain

[4] CIOCC, Ona 10, Madrid 28050, Spain

[5] Hosp Univ HM Torrelodones, Serv Oncol Clin, Castillo Olivares S-N, Torrelodones 28250, Spain

[6] San Pablo CEU, Sch Med, Calle Julian Romea,18, Madrid 28003, Spain

[7] Shanghai Jiao Tong Univ, Key Lab Thin Film & Microfabricat Technol, Inst Nano Biomed & Engn,Sch Elect Informat & Elec, Minist Educ,Dept Instrument Sci & Engn,Natl Ctr T, Shanghai 200240, Peoples R China

[8] Univ Hamburg, Fachbereich Phys & Chem, D-20146 Hamburg, Germany

[9] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, Carrer Marcelli Domingo S-N, E-43007 Tarragona, Spain

[10] ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain

来源：

LANGMUIR | 2017年 / 33卷 / 38期

关键词：

SURFACE-ENHANCED RAMAN; CIRCULATING TUMOR-CELLS; SINGLE-MOLECULE DETECTION; IN-VIVO; C-MYC; ULTRASENSITIVE DETECTION; CANCER-DETECTION; SELECTION-RULES; RAPID DETECTION; GOLD NANOSTARS;

D O I：

10.1021/acs.langmuir.7b01567

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Changes in protein expression levels and protein structure may indicate genomic mutations and may be related to some diseases. Therefore, the precise quantification and characterization of proteins can be used for disease diagnosis. Compared with several other alternative methods, surface enhanced Raman scattering (SERS) spectroscopy is regarded as an excellent choice for the quantification and structural characterization of proteins. Herein, we review the main advance of using plasmonic nanostructures as SERS sensing platform for this purpose. Three design approaches, including direct SERS, indirect SERS, and SERS-encoded nanoparticles, are discussed in the direction of developing new precise approaches of quantification and characterization of proteins. While this Review is focused on proteins, in order to highlight concepts of SERS-based sensors also detection of other biomolecules will be discussed.

引用

页码：9711 / 9730

页数：20

共 144 条

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