Transformation of Polycythemia Vera to Pure Erythroid Leukemia

被引：1

作者：

Liu, Louisa ^{[1
]}

Dudheker, Neil ^{[2
]}

Lezama, Lhara M. Sumarriva ^{[3
]}

Shah, Sameer ^{[4
]}

Nwaokoro, Maureen ^{[5
]}

Ranpura, Vishal ^{[6
]}

机构：

[1] Univ Calif Riverside, Internal Med, Riverside, CA 92521 USA

[2] Univ Calif San Diego, Hematol & Oncol, San Diego, CA 92103 USA

[3] Kaiser Permanente, Pathol, Los Angeles, CA USA

[4] Univ Calif Riverside, Hematol & Oncol, Riverside, CA 92521 USA

[5] Univ Calif Riverside, Internal Med, Riverside, CA 92521 USA

[6] Kaiser Permanente, Hematol & Oncol, Riverside, CA USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 07期

关键词：

polycythemia vera; leukemic transformation; chronic myeloproliferative neoplasms; pure erythroid leukemia; hydroxyurea; ESSENTIAL THROMBOCYTHEMIA; RISK; NEOPLASMS;

D O I：

10.7759/cureus.16168

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pure erythroid leukemia (PEL) is an aggressive and exceedingly rare form of acute leukemia characterized as a neoplastic proliferation of immature cells committed to the erythroid lineage. It has a poor overall median survival of two to three months. To our knowledge, there are currently only a handful of reports of PEL arising from polycythemia vera. Most reported cases have been associated with radiation therapy or chemotherapeutic alkylating agents. Here we report a rare occurrence of polycythemia vera treated with phlebotomy and hydroxyurea that underwent leukemic transformation to pure erythroid leukemia.

引用

页数：6

共 23 条

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