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- [31] Immune Checkpoint Inhibitors in Cancer TherapyCURRENT ONCOLOGY, 2022, 29 (05) : 3044 - 3060论文数: 引用数: h-index:机构:Khodadadi, Faezeh论文数: 0 引用数: 0 h-index: 0机构: PES Univ, Fac Pharmaceut Sci, PES Coll Pharm, Bengaluru 560085, India Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, Italy论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Hosseini, Shadi论文数: 0 引用数: 0 h-index: 0机构: Kurdistan Univ Med Sci, Res Inst Hlth Dev, Cellular & Mol Res Ctr, Sanandaj 6617713446, Iran Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, ItalySadeghirad, Habib论文数: 0 引用数: 0 h-index: 0机构: Univ Queensland, Diamantina Inst, Fac Med, Brisbane, Qld 4102, Australia Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, ItalyLadwa, Rahul论文数: 0 引用数: 0 h-index: 0机构: Princess Alexandra Hosp, Brisbane, Qld 4102, Australia Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, ItalyO'Byrne, Ken论文数: 0 引用数: 0 h-index: 0机构: Princess Alexandra Hosp, Brisbane, Qld 4102, Australia Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, ItalyKulasinghe, Arutha论文数: 0 引用数: 0 h-index: 0机构: Univ Queensland, Diamantina Inst, Fac Med, Brisbane, Qld 4102, Australia Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80138 Naples, Italy
- [32] Clinical implications of homologous recombination repair mutations in prostate cancerPROSTATE, 2022, 82 : S45 - S59Cresta Morgado, Pablo论文数: 0 引用数: 0 h-index: 0机构: Vall dHebron Univ Hosp, Prostate Canc Translat Res Grp, Vall dHebron Inst Oncol VHIO, Med Oncol Dept, 115-117 Natzaret,Off 402, Barcelona 08035, Spain Vall dHebron Univ Hosp, Prostate Canc Translat Res Grp, Vall dHebron Inst Oncol VHIO, Med Oncol Dept, 115-117 Natzaret,Off 402, Barcelona 08035, SpainMateo, Joaquin论文数: 0 引用数: 0 h-index: 0机构: Vall dHebron Univ Hosp, Prostate Canc Translat Res Grp, Vall dHebron Inst Oncol VHIO, Med Oncol Dept, 115-117 Natzaret,Off 402, Barcelona 08035, Spain Vall dHebron Univ Hosp, Prostate Canc Translat Res Grp, Vall dHebron Inst Oncol VHIO, Med Oncol Dept, 115-117 Natzaret,Off 402, Barcelona 08035, Spain
- [33] A comprehensive literature review and meta-analysis of the prevalence of pan-cancer BRCA mutations, homologous recombination repair gene mutations, and homologous recombination deficienciesENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2022, 63 (06) : 308 - 316Shao, Changxia论文数: 0 引用数: 0 h-index: 0机构: Merck & Co Inc, Rahway, NJ 07065 USA Merck & Co Inc, Rahway, NJ 07065 USAWan, Jun论文数: 0 引用数: 0 h-index: 0机构: Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA Merck & Co Inc, Rahway, NJ 07065 USALam, Fred C.论文数: 0 引用数: 0 h-index: 0机构: Donald & Barbara Zucker Sch Med Hofstra Northwell, North Shore Univ Hosp, Northwell Hlth, Dept Neurosurg, Manhasset, NY USA Merck & Co Inc, Rahway, NJ 07065 USATang, Huilin论文数: 0 引用数: 0 h-index: 0机构: Integrat Precis Hlth LLC, Carmel, IN USA Merck & Co Inc, Rahway, NJ 07065 USAMarley, Andrew R.论文数: 0 引用数: 0 h-index: 0机构: Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA Merck & Co Inc, Rahway, NJ 07065 USASong, Yiqing论文数: 0 引用数: 0 h-index: 0机构: Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA Merck & Co Inc, Rahway, NJ 07065 USAMiller, Chelsey论文数: 0 引用数: 0 h-index: 0机构: Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA Merck & Co Inc, Rahway, NJ 07065 USABrown, Madeline论文数: 0 引用数: 0 h-index: 0机构: Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA Merck & Co Inc, Rahway, NJ 07065 USAHan, Jiali论文数: 0 引用数: 0 h-index: 0机构: Integrat Precis Hlth LLC, Carmel, IN USA Merck & Co Inc, Rahway, NJ 07065 USAAdeboyeje, Gboyega论文数: 0 引用数: 0 h-index: 0机构: Merck & Co Inc, Rahway, NJ 07065 USA Merck & Co Inc, Rahway, NJ 07065 USA
- [34] Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patientsPATHOLOGY RESEARCH AND PRACTICE, 2021, 224Jiang, Xingran论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaHu, Xiumei论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaGu, Yajuan论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaLi, Yunlong论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaJin, Mulan论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaZhao, Hongying论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaGao, Ruixia论文数: 0 引用数: 0 h-index: 0机构: Amoy Diagnost Co Ltd, Xiamen, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaHuang, Zhan论文数: 0 引用数: 0 h-index: 0机构: Amoy Diagnost Co Ltd, Xiamen, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R ChinaLu, Jun论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China
- [35] Effect of KDR mutations on efficacy of immune checkpoint inhibitors in patients with bladder cancer.JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)Dai, Honghai论文数: 0 引用数: 0 h-index: 0机构: Shandong Prov Hosp, Jinan, Shandong, Peoples R ChinaZhang, Qin论文数: 0 引用数: 0 h-index: 0机构: Shandong Prov Hosp, Jinan, Shandong, Peoples R ChinaTan, Yuan论文数: 0 引用数: 0 h-index: 0机构: Shandong Prov Hosp, Jinan, Shandong, Peoples R ChinaDuan, Qianqian论文数: 0 引用数: 0 h-index: 0机构: Shandong Prov Hosp, Jinan, Shandong, Peoples R China
- [36] Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genesJOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (06)Trigos, Anna Sofia论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaPasam, Anupama论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaBanks, Patricia论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaWallace, Roslyn论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaGuo, Christina论文数: 0 引用数: 0 h-index: 0机构: Inst Canc Res Sutton, Sutton, Surrey, England Royal Marsden Hosp Sutton, Sutton, Surrey, England Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaKeam, Simon论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaThorne, Heather论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaMitchell, Catherine论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Dept Pathol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaLade, Stephen论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Dept Pathol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, 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0机构: Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaBolton, Damien论文数: 0 引用数: 0 h-index: 0机构: Austin Hosp, Heidelberg, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaMoon, Daniel论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaDarcy, Phil论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaHaupt, Ygal论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaWilliams, Scott G.论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Radiat Oncol & Canc Imaging, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaCastro, Elena论文数: 0 引用数: 0 h-index: 0机构: Inst Invest Biomed Malaga, Malaga, Spain Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaOlmos, David论文数: 0 引用数: 0 h-index: 0机构: Inst Invest Biomed Malaga, Malaga, Spain Inst Invest Hosp 12 Octubre, Med Oncol Dept, Madrid, Spain Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaGoode, David论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaNeeson, Paul论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, AustraliaSandhu, Shahneen论文数: 0 引用数: 0 h-index: 0机构: Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia
- [37] Results and challenges of immune checkpoint inhibitors in colorectal cancerEXPERT OPINION ON BIOLOGICAL THERAPY, 2018, 18 (05) : 561 - 573Emambux, Sheik论文数: 0 引用数: 0 h-index: 0机构: Univ Poitiers Hosp, Dept Med Oncol, Poitiers, France Univ Poitiers Hosp, Dept Med Oncol, Poitiers, FranceTachon, Gaelle论文数: 0 引用数: 0 h-index: 0机构: Univ Poitiers Hosp, Dept Canc Biol, Poitiers, France Univ Poitiers, Cellular Therapies Brain Dis Grp, Expt & Clin Neurosci Lab, INSERM,U1084, Poitiers, France Univ Poitiers, Fac Med, Poitiers, France Univ Poitiers Hosp, Dept Med Oncol, Poitiers, FranceJunca, Audelaure论文数: 0 引用数: 0 h-index: 0机构: Univ Poitiers, Fac Med, Poitiers, France Univ Poitiers Hosp, Dept Pathol, Poitiers, France Univ Poitiers Hosp, Dept Med Oncol, Poitiers, FranceTougeron, David论文数: 0 引用数: 0 h-index: 0机构: Univ Poitiers Hosp, Dept Med Oncol, Poitiers, France Univ Poitiers, Fac Med, Poitiers, France Univ Poitiers Hosp, Dept Gastroenterol, Poitiers, France Univ Poitiers Hosp, Dept Med Oncol, Poitiers, France
- [38] Immune Checkpoint Inhibitors in pMMR/MSS Colorectal CancerJOURNAL OF GASTROINTESTINAL CANCER, 2023, 54 (04) : 1017 - 1030El Hajj, Joanna论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA UT Southwestern Med Ctr, Div Hematol & Oncol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USAReddy, Sarah论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USAVerma, Nilesh论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA UT Southwestern Med Ctr, Div Hematol & Oncol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USAHuang, Emina H.论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Med Ctr, Dept Surg, Div Surg Oncol, Dallas, TX USA UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USAKazmi, Syed M.论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA UT Southwestern Med Ctr, Div Hematol & Oncol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
- [39] Immune checkpoint inhibitors in colorectal cancer: limitation and challengesFRONTIERS IN IMMUNOLOGY, 2024, 15Yan, Suying论文数: 0 引用数: 0 h-index: 0机构: Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaWang, Wanting论文数: 0 引用数: 0 h-index: 0机构: Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaFeng, Zhiqiang论文数: 0 引用数: 0 h-index: 0机构: Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaXue, Jun论文数: 0 引用数: 0 h-index: 0机构: Hebei North Univ, Dept Gen Surg, Affiliated Hosp 1, Zhangjiakou, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaLiang, Weizheng论文数: 0 引用数: 0 h-index: 0机构: Hebei North Univ, Cent Lab, Affiliated Hosp 1, Zhangjiakou, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaWu, Xueliang论文数: 0 引用数: 0 h-index: 0机构: Hebei North Univ, Dept Gen Surg, Affiliated Hosp 1, Zhangjiakou, Peoples R China Hebei North Univ, Inst Canc, Affiliated Hosp 1, Zhangjiakou, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaTan, Zhiquan论文数: 0 引用数: 0 h-index: 0机构: Tianjin Union Med Ctr, Dept Sci & Tech Informat, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaZhang, Xipeng论文数: 0 引用数: 0 h-index: 0机构: Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin, Peoples R China Nankai Univ, Inst Translat Med, Tianjin Union Med Ctr, Tianjin, Peoples R China Tianjin Inst Coloproctol, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaZhang, Shuai论文数: 0 引用数: 0 h-index: 0机构: Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaLi, Xichuan论文数: 0 引用数: 0 h-index: 0机构: Tianjin Normal Univ, Coll Life Sci, Tianjin Key Lab Anim & Plant Resistance, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R ChinaZhang, Chunze论文数: 0 引用数: 0 h-index: 0机构: Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin, Peoples R China Nankai Univ, Inst Translat Med, Tianjin Union Med Ctr, Tianjin, Peoples R China Tianjin Inst Coloproctol, Tianjin, Peoples R China Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin, Peoples R China
- [40] Immune Checkpoint Inhibitors in pMMR/MSS Colorectal CancerJournal of Gastrointestinal Cancer, 2023, 54 : 1017 - 1030Joanna El Hajj论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Medical Center,Department of Internal MedicineSarah Reddy论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Medical Center,Department of Internal MedicineNilesh Verma论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Medical Center,Department of Internal MedicineEmina H. Huang论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Medical Center,Department of Internal MedicineSyed M. Kazmi论文数: 0 引用数: 0 h-index: 0机构: UT Southwestern Medical Center,Department of Internal Medicine