Role of GABA in anxiety and depression

被引：389

作者：

Kalueff, Allan V.

Nutt, David J. ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Psychopharmacol Unit, Bristol BS8 1TD, Avon, England

[2] NIMH, Clin Sci Lab, Bethesda, MD 20892 USA

来源：

DEPRESSION AND ANXIETY | 2007年 / 24卷 / 07期

关键词：

GABA; anxiety; depression; benzodiazepine receptors; common pathogenesis;

D O I：

10.1002/da.20262

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.

引用

页码：495 / 517

页数：23

共 348 条

[1]

ALEY KO, 1989, N-S ARCH PHARMACOL, V339, P306

[2]

Altshuler L L, 1999, Bipolar Disord, V1, P61, DOI 10.1034/j.1399-5618.1999.10113.x

[3]

AMANO K, 1978, APPL NEUROPHYSIOL, V41, P66

[4] The role of corticotropin-releasing factor in depression and anxiety disorders [J].