Human Infections with Non-O157 Shiga Toxin-producing Escherichia coli, Switzerland, 2000-2009

被引：98
作者：
Kaeppeli, Ursula
Haechler, Herbert
Giezendanner, Nicole
Beutin, Lothar [2 ]
Stephan, Roger [1 ]
机构：
[1] Univ Zurich, Inst Food Safety & Hyg, Vetsuisse Fac, CH-8057 Zurich, Switzerland
[2] Fed Inst Risk Assessment, Berlin, Germany
来源：
EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 02期
关键词：
HEMOLYTIC-UREMIC SYNDROME; COLI INFECTIONS; ANTIMICROBIAL RESISTANCE; MOLECULAR ANALYSIS; VIRULENCE GENES; STRAINS; SEROTYPES; DISEASE; FOOD; IDENTIFICATION;
D O I：
10.3201/eid1702.100909
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We characterized 97 non-O157 Shiga toxin (stx)-producing Escherichia coli strains isolated from human patients during 2000-2009 from the national reference laboratory in Switzerland. These strains belonged to 40 O:H serotypes; 4 serotypes (O26:H11/H-, O103:H2, O121:H19, and O145:H28/H-) accounted for 46.4% of the strains. Nonbloody diarrhea was reported by 23.2% of the patients, bloody diarrhea by 56.8%. Hemolytic uremic syndrome developed in 40.0% of patients; serotype O26:H11/H- was most often associated with this syndrome. Forty-five (46.4%) strains carried stx2 genes only, 36 strains (37.1%) carried stx1, and 16 (16.5%) strains carried stx1 and stx2. Genes encoding enterohemolysin and intimin were detected in 75.3% and 70.1% of the strains, respectively. Resistance to >= 1 antimicrobial agent was present in 25 isolates. High genetic diversity within strains indicates that non-O157 stx producing E. coli infections in Switzerland most often occurred as single cases.
引用
收藏
页码：180 / 185
页数：6
相关论文
共 33 条
[1]  
[Anonymous], 2009, PulseNet
[2]   The non-O157 Shiga-Toxigenic (Verocytotoxigenic) Escherichia coli; under-rated pathogens [J].
Bettelheim, Karl A. .
CRITICAL REVIEWS IN MICROBIOLOGY, 2007, 33 (01) :67-87
[3]   Characterization of Shiga toxin-producing Escherichia coli strains isolated from human patients in Germany over a 3-year period [J].
Beutin, L ;
Krause, G ;
Zimmermann, S ;
Kaulfuss, S ;
Gleier, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (03) :1099-1108
[4]   Identification of human-pathogenic strains of Shiga toxin-producing Escherichia coli from food by a combination of serotyping and molecular typing of Shiga toxin genes [J].
Beutin, Lothar ;
Miko, Angelika ;
Krause, Gladys ;
Pries, Karin ;
Haby, Sabine ;
Steege, Katja ;
Albrecht, Nadine .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (15) :4769-4775
[5]   Molecular profiling and phenotype analysis of Escherichia coli O26:H11 and O26:NM:: Secular and geographic consistency of enterohemorrhagic and enteropathogenic isolates [J].
Bielaszewska, M ;
Zhang, WL ;
Tarr, PI ;
Sonntag, AK ;
Karch, H .
JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :4225-4228
[6]   Shiga Toxin, Cytolethal Distending Toxin, and Hemolysin Repertoires in Clinical Escherichia coli O91 Isolates [J].
Bielaszewska, Martina ;
Stoewe, Franziska ;
Fruth, Angelika ;
Zhang, Wenlan ;
Prager, Rita ;
Brockmeyer, Jens ;
Mellmann, Alexander ;
Karch, Helge ;
Friedrich, Alexander W. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (07) :2061-2066
[7]   Serotypes, virulence genes, and intimin types of Shiga toxin (verotoxin)-producing Escherichia coli isolates from human patients:: Prevalence in Lugo, Spain, from 1992 through 1999 [J].
Blanco, JE ;
Blanco, M ;
Alonso, MP ;
Mora, A ;
Dahbi, G ;
Coira, MA ;
Blanco, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (01) :311-319
[8]   Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans [J].
Boerlin, P ;
McEwen, SA ;
Boerlin-Petzold, F ;
Wilson, JB ;
Johnson, RP ;
Gyles, CL .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :497-503
[9]   Non-O157 shiga toxin-producing Escherichia coli infections in the United States, 1983-2002 [J].
Brooks, JT ;
Sowers, EG ;
Wells, JG ;
Greene, KD ;
Griffin, PM ;
Hoekstra, RM ;
Strockbine, NA .
JOURNAL OF INFECTIOUS DISEASES, 2005, 192 (08) :1422-1429
[10]  
*CDCP, FOODNET FOODB ACT SU
1234