共 105 条
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
被引:58
作者:

Foulkes, Daniel M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Byrne, Dominic P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

论文数: 引用数:
h-index:
机构:

Shrestha, Safal
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Bailey, Fiona P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Ferries, Samantha
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
Univ Liverpool, Ctr Proteome Res, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Eyers, Claire E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
Univ Liverpool, Ctr Proteome Res, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

论文数: 引用数:
h-index:
机构:

Wells, Carrow
论文数: 0 引用数: 0
h-index: 0
机构:
Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Drewry, David H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Zuercher, William J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA
Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Kannan, Natarajan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
机构:
[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
[2] Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA
[3] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
[4] Univ Liverpool, Ctr Proteome Res, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
[5] Univ Glasgow, Paul OGorman Leukaemia Res Ctr, Inst Canc Sci, Glasgow, Lanark, Scotland
[6] Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA
[7] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
基金:
英国生物技术与生命科学研究理事会;
巴西圣保罗研究基金会;
加拿大创新基金会;
英国惠康基金;
关键词:
NONCATALYTIC FUNCTIONS;
STRUCTURAL-ANALYSIS;
RESISTANT AURORA;
C/EBP-ALPHA;
BIBW;
2992;
BINDING;
TARGET;
DOMAIN;
ACTIVATION;
DISCOVERY;
D O I:
10.1126/scisignal.aat7951
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
A major challenge associated with biochemical and cellular analysis of pseudokinases is a lack of target-validated small-molecule compounds with which to probe function. Tribbles 2 (TRIB2) is a cancer-associated pseudokinase with a diverse interactome, including the canonical AKT signaling module. There is substantial evidence that human TRIB2 promotes survival and drug resistance in solid tumors and blood cancers and therefore is of interest as a therapeutic target. The unusual TRIB2 pseudokinase domain contains a unique cysteine-rich C-helix and interacts with a conserved peptide motif in its own carboxyl-terminal tail, which also supports its interaction with E3 ubiquitin ligases. We found that TRIB2 is a target of previously described small-molecule protein kinase inhibitors, which were originally designed to inhibit the canonical kinase domains of epidermal growth factor receptor tyrosine kinase family members. Using a thermal shift assay, we discovered TRIB2-binding compounds within the Published Kinase Inhibitor Set (PKIS) and used a drug repurposing approach to classify compounds that either stabilized or destabilized TRIB2 in vitro. TRIB2 destabilizing agents, including the covalent drug afatinib, led to rapid TRIB2 degradation in human AML cancer cells, eliciting tractable effects on signaling and survival. Our data reveal new drug leads for the development of TRIB2-degrading compounds, which will also be invaluable for unraveling the cellular mechanisms of TRIB2-based signaling. Our study highlights that small molecule-induced protein down-regulation through drug "off-targets" might be relevant for other inhibitors that serendipitously target pseudokinases.
引用
收藏
页数:14
相关论文
共 105 条
[1]
Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein
[J].
Aertgeerts, Kathleen
;
Skene, Robert
;
Yano, Jason
;
Sang, Bi-Ching
;
Zou, Hua
;
Snell, Gyorgy
;
Jennings, Andy
;
Iwamoto, Keiji
;
Habuka, Noriyuki
;
Hirokawa, Aki
;
Ishikawa, Tomoyasu
;
Tanaka, Toshimasa
;
Miki, Hiroshi
;
Ohta, Yoshikazu
;
Sogabe, Satoshi
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2011, 286 (21)
:18756-18765

Aertgeerts, Kathleen
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Skene, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Yano, Jason
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Sang, Bi-Ching
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Zou, Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Snell, Gyorgy
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Jennings, Andy
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda San Diego Inc, San Diego, CA 92121 USA Takeda San Diego Inc, San Diego, CA 92121 USA

Iwamoto, Keiji
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Yodogawa Ku, Osaka 5328686, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Habuka, Noriyuki
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Yodogawa Ku, Osaka 5328686, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Hirokawa, Aki
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Yodogawa Ku, Osaka 5328686, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Ishikawa, Tomoyasu
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Tsukuba, Ibaraki 3004293, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Tanaka, Toshimasa
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Yodogawa Ku, Osaka 5328686, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Miki, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Yodogawa Ku, Osaka 5328686, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Ohta, Yoshikazu
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Tsukuba, Ibaraki 3004293, Japan Takeda San Diego Inc, San Diego, CA 92121 USA

Sogabe, Satoshi
论文数: 0 引用数: 0
h-index: 0
机构:
Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Yodogawa Ku, Osaka 5328686, Japan Takeda San Diego Inc, San Diego, CA 92121 USA
[2]
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumourgrowth
[J].
Bago, Ruzica
;
Sommer, Eeva
;
Castel, Pau
;
Crafter, Claire
;
Bailey, Fiona P.
;
Shpiro, Natalia
;
Baselga, Jose
;
Cross, Darren
;
Eyers, Patrick A.
;
Alessi, Dario R.
.
EMBO JOURNAL,
2016, 35 (17)
:1902-1922

Bago, Ruzica
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Sommer, Eeva
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Castel, Pau
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Crafter, Claire
论文数: 0 引用数: 0
h-index: 0
机构:
AstraZeneca, CRUK Cambridge Inst, Oncol iMED, Cambridge, England Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Bailey, Fiona P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Shpiro, Natalia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Baselga, Jose
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Cross, Darren
论文数: 0 引用数: 0
h-index: 0
机构:
AstraZeneca, CRUK Cambridge Inst, Oncol iMED, Cambridge, England Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland

Alessi, Dario R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland
[3]
Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics
[J].
Bailey, Fiona P.
;
Clarke, Kim
;
Kalirai, Helen
;
Kenyani, Jenna
;
Shahidipour, Haleh
;
Falciani, Francesco
;
Coulson, Judy M.
;
Sacco, Joseph J.
;
Coupland, Sarah E.
;
Eyers, Patrick A.
.
PIGMENT CELL & MELANOMA RESEARCH,
2018, 31 (02)
:253-266

Bailey, Fiona P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Clarke, Kim
论文数: 0 引用数: 0
h-index: 0
机构: Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Kalirai, Helen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Translat Res, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Kenyani, Jenna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Translat Res, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Shahidipour, Haleh
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Translat Res, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Falciani, Francesco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Computat Biol Facil, Funct & Comparat Genom, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Coulson, Judy M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Translat Res, Cellular & Mol Physiol, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Sacco, Joseph J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Translat Res, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Coupland, Sarah E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Translat Res, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England
[4]
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner
[J].
Bailey, Fiona P.
;
Byrne, Dominic P.
;
Oruganty, Krishnadev
;
Eyers, Claire E.
;
Novotny, Christopher J.
;
Shokat, Kevan M.
;
Kannan, Natarajan
;
Eyers, Patrick A.
.
BIOCHEMICAL JOURNAL,
2015, 467
:47-62

Bailey, Fiona P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Byrne, Dominic P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

论文数: 引用数:
h-index:
机构:

Eyers, Claire E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Novotny, Christopher J.
论文数: 0 引用数: 0
h-index: 0
机构:
UCSF, Dept Cellular & Mol Pharmacol, Howard Hughes Med Inst, San Francisco, CA 94158 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Shokat, Kevan M.
论文数: 0 引用数: 0
h-index: 0
机构:
UCSF, Dept Cellular & Mol Pharmacol, Howard Hughes Med Inst, San Francisco, CA 94158 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Kannan, Natarajan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
[5]
Going for broke: targeting the human cancer pseudokinome
[J].
Bailey, Fiona P.
;
Byrne, Dominic P.
;
McSkimming, Daniel
;
Kannan, Natarajan
;
Eyers, Patrick A.
.
BIOCHEMICAL JOURNAL,
2015, 465
:195-211

Bailey, Fiona P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Byrne, Dominic P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

McSkimming, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Kannan, Natarajan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA
Univ Georgia, Biochem & Mol Biol, Athens, GA 30602 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
[6]
Covalent docking using autodock: Two-point attractor and flexible side chain methods
[J].
Bianco, Giulia
;
Forli, Stefano
;
Goodsell, David S.
;
Olson, Arthur J.
.
PROTEIN SCIENCE,
2016, 25 (01)
:295-301

Bianco, Giulia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cagliari, Drug Sci Sect, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy Univ Cagliari, Drug Sci Sect, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy

Forli, Stefano
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Mol Graph Lab, Dept Integrat Struct & Computat Biol, MB 112,10550 North Torrey Pines Rd, La Jolla, CA 92037 USA Univ Cagliari, Drug Sci Sect, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy

Goodsell, David S.
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Mol Graph Lab, Dept Integrat Struct & Computat Biol, MB 112,10550 North Torrey Pines Rd, La Jolla, CA 92037 USA Univ Cagliari, Drug Sci Sect, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy

Olson, Arthur J.
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Mol Graph Lab, Dept Integrat Struct & Computat Biol, MB 112,10550 North Torrey Pines Rd, La Jolla, CA 92037 USA Univ Cagliari, Drug Sci Sect, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy
[7]
Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer
[J].
Bose, Prithviraj
;
Ozer, Howard
.
EXPERT OPINION ON INVESTIGATIONAL DRUGS,
2009, 18 (11)
:1735-1751

Bose, Prithviraj
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Hematol Oncol Sect, Oklahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Hematol Oncol Sect, Oklahoma City, OK 73104 USA

Ozer, Howard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Hematol Oncol Sect, Oklahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Hematol Oncol Sect, Oklahoma City, OK 73104 USA
[8]
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
[J].
Byrne, Dominic P.
;
Li, Yong
;
Ngamlert, Pawin
;
Ramakrishnan, Krithika
;
Eyers, Claire E.
;
Wells, Carrow
;
Drewry, David H.
;
Zuercher, William J.
;
Berry, Neil G.
;
Fernig, David G.
;
Eyers, Patrick A.
.
BIOCHEMICAL JOURNAL,
2018, 475
:2435-2455

Byrne, Dominic P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Li, Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Ngamlert, Pawin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Ramakrishnan, Krithika
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Eyers, Claire E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
Univ Liverpool, Inst Integrat Biol, Ctr Proteome Res, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Wells, Carrow
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Drewry, David H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Zuercher, William J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, UNC Eshelman Sch Pharm, Struct Genom Consortium, Chapel Hill, NC 27599 USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Berry, Neil G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Fernig, David G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England
[9]
Pseudokinases: update on their functions and evaluation as new drug targets
[J].
Byrne, Dominic P.
;
Foulkes, Daniel M.
;
Eyers, Patrick A.
.
FUTURE MEDICINAL CHEMISTRY,
2017, 9 (02)
:245-265

Byrne, Dominic P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Foulkes, Daniel M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England
[10]
cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry
[J].
Byrne, Dominic P.
;
Vonderach, Matthias
;
Ferries, Samantha
;
Brownridge, Philip J.
;
Eyers, Claire E.
;
Eyers, Patrick A.
.
BIOCHEMICAL JOURNAL,
2016, 473
:3159-3175

Byrne, Dominic P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England

Vonderach, Matthias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England

Ferries, Samantha
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England

Brownridge, Philip J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England

Eyers, Claire E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England

Eyers, Patrick A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L69 7ZB, Merseyside, England