Novel Method for Synthesizing Spiro[4.5]cyclohexadienones through a Pd-Catalyzed Intramolecular ipso-Friedel-Crafts Allylic Alkylation of Phenols

被引：227

作者：

Nemoto, Tetsuhiro ^{[1
]}

Ishige, Yuta ^{[1
]}

Yoshida, Mariko ^{[1
]}

Kohno, Yuta ^{[1
]}

Kanematsu, Mutsumi ^{[1
]}

Hamada, Yasumasa ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 21期

关键词：

ENANTIOSELECTIVE CONSTRUCTION; ASYMMETRIC-SYNTHESIS; QUATERNARY STEREOCENTERS; CYCLIZATION; ALLYLATION; METAL; DEAROMATIZATION; NUCLEOPHILES; COMPLEXES; KETONES;

D O I：

10.1021/ol102190s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first successful Pd-catalyzed intramolecular ipso-Friedel Crafts allylic alkylation of phenols, which provided a new access to spiro[4.5]cyclohexadienones, is described. The present method could be applied to catalytic enantioselective construction of an all-carbon quaternary spirocenter.

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页码：5020 / 5023

页数：4

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