Novel Method for Synthesizing Spiro[4.5]cyclohexadienones through a Pd-Catalyzed Intramolecular ipso-Friedel-Crafts Allylic Alkylation of Phenols

被引：227
作者：
Nemoto, Tetsuhiro [1 ]
Ishige, Yuta [1 ]
Yoshida, Mariko [1 ]
Kohno, Yuta [1 ]
Kanematsu, Mutsumi [1 ]
Hamada, Yasumasa [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 21期
关键词：
ENANTIOSELECTIVE CONSTRUCTION; ASYMMETRIC-SYNTHESIS; QUATERNARY STEREOCENTERS; CYCLIZATION; ALLYLATION; METAL; DEAROMATIZATION; NUCLEOPHILES; COMPLEXES; KETONES;
D O I：
10.1021/ol102190s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first successful Pd-catalyzed intramolecular ipso-Friedel Crafts allylic alkylation of phenols, which provided a new access to spiro[4.5]cyclohexadienones, is described. The present method could be applied to catalytic enantioselective construction of an all-carbon quaternary spirocenter.
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页码：5020 / 5023
页数：4
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