Occurrence of monocytoid B-cells in reactive lymph node lesions

被引:10
作者
Kojima, M
Nakamura, S
Itoh, H
Yoshida, K
Shimizu, K
Motoori, T
Yamane, N
Joshita, T
Suchi, T
机构
[1] Ashikaga Red Cross Hosp, Dept Pathol & Clin Labs, Ashikaga, Tochigi 3260808, Japan
[2] Aichi Canc Ctr Hosp, Dept Pathol & Clin Labs, Nagoya, Aichi 464, Japan
[3] Maebashi Red Cross Hosp, Dept Pathol & Clin Labs, Maebashi, Gumma, Japan
[4] Kiryu Welf Gen Hosp, Dept Pathol & Clin Labs, Kiryu, Gumma, Japan
[5] Natl Tochigi Hosp, Dept Pathol & Clin Labs, Utsunomiya, Tochigi, Japan
[6] Kitasato Med Ctr Hosp, Dept Pathol, Kitamoto, Japan
[7] Gunma Univ, Sch Med, Dept Clin Labs, Maebashi, Gumma 371, Japan
关键词
monocytoid B-cells; follicular hyperplasia; epithelioid cells; bcl-2; protein; Epstein-Barr virus;
D O I
10.1016/S0344-0338(98)80045-9
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Benign monocytoid B-cells are a peculiar subset of B-cells. They are closely related to marginal zone B-lymphocytes, show cytological diversity and may be recognized in a variety of reactive lymph node conditions. To analyze the incidence, cytological spectrum and phenotypic features of benign monocytoid B-cells, we investigated a series of 301 consecutively biopsied and unselected cases of reactive lymph node change from 1988 and 1995. A monocytoid B-cell reaction was identified in 46 (15%) cases and could be cytologically subclassifled into two groups: 31 (67%) cases with common-type cells and 15 (33%) cases with large, transformed cells, according to the description by Plank et al. [19]. These reactions were regularly associated with follicular hyperplasia (95%) and were part of an epithelioid cell response in 24 cases (50%). Immunohistologically, both types of benign monocytoid B-cells were negative for bcl-2 protein expression, which was in contrast to the bcl-2 positive reaction in marginal zone B-lymphocytes and their neoplastic counterpart in monocytoid B-cell lymphoma. An association of Epstein-Barr virus (EBV) with monocytoid B-cells was investigated by in situ-hybridization. EBV genomes were detected in five (15%) of 31 cases tested. In each of these five cases, positive cells were represented in both high and low numbers. The morphologic features of the EBV-positive cells were not consistent with monocytoid B-cells, but rather with medium-sized to large lymphoid cells. It appeared that the occurrence of monocytoid B-cell reaction in reactive lymph node lesions was not related to EBV infection in the majority of cases.
引用
收藏
页码:559 / 565
页数:7
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