Pea3 transcription factor promotes neurite outgrowth

被引：8
|
作者：
Kandemir, Basak [1 ]
Caglayan, Berrak [1 ,2 ]
Hausott, Barbara [2 ]
Erdogan, Burcu [1 ]
Dag, Ugur [1 ]
Demir, Ozlem [1 ]
Sogut, Melis S. [1 ]
Klimaschewski, Lars [2 ]
Kurnaz, Isil A. [1 ]
机构：
[1] Yeditepe Univ, Dept Genet & Bioengn, Mol Neurobiol Lab, TR-34755 Istanbul, Turkey
[2] Med Univ Innsbruck, Div Neuroanat, A-6020 Innsbruck, Austria
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2014年 / 7卷
关键词：
Pea3; neuron; axonal outgrowth; phosphorylation; neurofilaments; ETS ONCOGENE FAMILY; MOTOR-NEURON POOLS; MOLECULAR CHARACTERIZATION; EXPRESSION PATTERNS; SENSORY NEURONS; GENE PEA3; DIFFERENTIATION; SPECIFICATION; ACTIVATION; PROTEIN;
D O I：
10.3389/fnmol.2014.00059
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3.
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收藏
页数：11
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