Timing of hepatitis B vaccination:: Its effect on vaccine response in health care workers

被引：14

作者：

Sabido, Meritxell ^{[1
]}

Gavalda, Laura ^{[1
]}

Olona, Noemi ^{[1
]}

Maria Ramon, Josep ^{[1
]}

机构：

[1] Hosp Univ Bellvitge, Dept Prevent Med & Publ Hlth, Hosp Llobregat, Lhospitalet De Llobregat 08907, Spain

来源：

VACCINE | 2007年 / 25卷 / 43期

关键词：

hepatitis B vaccine; dose schedule; immunogenicity;

D O I：

10.1016/j.vaccine.2007.08.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the effect of timing and other biological variables on immune response among health care workers (HCW) vaccinated with hepatitis B vaccine. A total of 2.058 HCW received three doses and were tested for anti-FlBs within 6 months. 92.2% of the HCW had evidence of seroprotection. Multivariable analysis showed that controlling for age, the estimated non-response OR associated with a delayed second dose was 2.16 (95% CI: 1.46, 3.18, p = 0.004). We found a decreasing response rate with increasing age. Particular attention should be given to those HCW who are late for the second vaccine dose and to older subjects. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7568 / 7572

页数：5

共 30 条

[1] Prediction of response to hepatitis B vaccine in health care workers: Whose titers of antibody to hepatitis B surface antigen should be determined after a three-dose series, and what are the implications in terms of cost-effectiveness? [J].