Facile access to versatile aza-macrolides through iridium-catalysed cascade allyl-amination/macrolactonization

被引：19

作者：

Fu, Wei ^{[1
]}

Wang, Lianhui ^{[1
]}

Yang, Zi ^{[1
]}

Shen, Jiang-Shan ^{[2
]}

Tang, Fei ^{[1
]}

Zhang, Jiayi ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Sch Biomed Sci, Minist Educ,Engn Res Ctr Mol Med, Key Lab Fujian Mol Med,Key Lab Xiamen Marine & Ge, Xiamen 361021, Peoples R China

[2] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 06期

关键词：

VINYLETHYLENE CARBONATES; DECARBOXYLATIVE CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; CONSTRUCTION; HETEROCYCLES; BOND; MACROLACTONIZATION; MACROCYCLIZATION; REARRANGEMENT; METATHESIS;

D O I：

10.1039/c9cc07372h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct access to benzo-fused aza-macrolides was successfully achieved through iridium-catalysed intermolecular decarboxylative coupling of vinylethylene carbonates with isatoic anhydrides under relatively mild reaction conditions. Notably, this reaction proceeded through sequential allyl-amination/macrolactonization upon extrusion of CO2. Moreover, favourable fluorescence properties could be observed in the title macrocyclic products.

引用

页码：960 / 963

页数：4

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