Association between triglyceride glucose index and carotid intima-media thickness in obese and nonobese adults

被引：12

作者：

Jia, Xiaojing ^{[1
,2
]}

Zhu, Yuanyue ^{[1
,2
]}

Qi, Yan ^{[1
,2
]}

Zheng, Ruizhi ^{[1
,2
]}

Lin, Lin ^{[1
,2
]}

Hu, Chunyan ^{[1
,2
]}

Zhang, Yi ^{[1
,2
]}

Wu, Xueyan ^{[1
,2
]}

Qi, Hongyan ^{[1
,2
]}

Wei, Ran ^{[1
,2
]}

Zhang, Jie ^{[1
,2
]}

Xu, Min ^{[1
,2
]}

Xu, Yu ^{[1
,2
]}

Wang, Tiange ^{[1
,2
]}

Zhao, Zhiyun ^{[1
,2
]}

Chen, Yuhong ^{[1
,2
]}

Bi, Yufang ^{[1
,2
]}

Wang, Weiqing ^{[1
,2
]}

Li, Mian ^{[1
,2
]}

Lu, Jieli ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp,Shanghai Key Lab Endocrine Tumor,Stat, Shanghai Natl Clin Res Ctr Metab Dis,Sch Med,Ruij, Key Lab Endocrine & Metab Dis,Natl Hlth Commiss P, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China

来源：

JOURNAL OF DIABETES | 2022年 / 14卷 / 09期

基金：

中国国家自然科学基金;

关键词：

carotid intima-media thickness; nonlinear relationship; obesity; triglyceride glucose index; BODY-MASS INDEX; INSULIN-RESISTANCE; WAIST CIRCUMFERENCE; FASTING GLUCOSE; ARTERY INTIMA; RISK-FACTORS; TYG INDEX; ATHEROSCLEROSIS; PRODUCT; DISEASE;

D O I：

10.1111/1753-0407.13312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The triglyceride glucose (TyG) index is closely associated with subclinical atherosclerosis. However, the association remains inconclusive among obese and nonobese individuals. Methods This prospective study was conducted in 5751 adults with normal carotid intima-media thickness (CIMT) at baseline. We divided the population into four groups based on the TyG index, which was calculated by the following formula: Ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL]/2). Information on CIMT was acquired by ultrasonography. Incident elevated CIMT was defined as IMT values greater than 0.9 mm at follow-up. Odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between TyG index and elevated CIMT were estimated using multivariable logistic regression models. Results After a median follow-up of 4.3 years, 722 (12.6%) individuals had progressed to elevated CIMT. Compared with the second quartile of the TyG index, the first and fourth quartile both conferred higher risks of elevated CIMT after adjusting for potential confounders. In the total population, the ORs for the first and fourth quartile were 1.29 (95% CI, 1.00-1.66) and 1.42 (95% CI, 1.11-1.83), respectively. Restricted cubic splines demonstrated an approximately U-shaped association between TyG index and elevated CIMT among the total and nonobese adults (P for nonlinearity <.05), but not in those with general or abdominal obesity. Conclusions A U-shaped association was observed between TyG index and elevated CIMT only among nonobese Chinese adults.

引用

页码：596 / 605

页数：10

共 49 条

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