ATP-Dependent Lon Proteases in the Cellular Protein Quality Control System

被引：3
作者：
Kudzhaev, A. M. [1 ]
Andrianova, A. G. [1 ]
Gustchina, A. E. [2 ]
Smirnov, I., V [1 ]
Rotanova, T., V [1 ]
机构：
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
[2] NCI, Prot Struct Sect, Ctr Struct Biol, Frederick, MD 21702 USA
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / 04期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
protein quality control system; AAA(+) proteins; molecular chaperones; ATP-dependent proteolysis; Lon proteases; 3D structure; cryo-EM; ESCHERICHIA-COLI LON; N-TERMINAL DOMAIN; CRYSTAL-STRUCTURE; SUBSTRATE-RECOGNITION; MOLECULAR CHAPERONES; STRUCTURAL INSIGHTS; REGULATORY PARTICLE; COMPLEX-FORMATION; CATALYTIC DOMAIN; OXIDATIVE STRESS;
D O I：
10.1134/S1068162022040136
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Protein Quality Control (PQC) system plays a leading role in maintaining the safety of the cellular proteome in all natural kingdoms. This review summarizes information about the structural and functional characteristics of molecular chaperones and energy-dependent proteases that form the PQC system, emphasizing the crucial role of proteins belonging to the AAA(+) superfamily, with the focus on ATP-dependent Lon proteases as a special family in the PQC. Similarities and differences among the enzymes of individual Lon subfamilies are discussed in detail using up-to-date data, elucidating the structural features and unique mechanisms of functioning of these proteins.
引用
收藏
页码：678 / 709
页数：32
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