Apoptotic-inducing factor 1 (AIF1) plays a critical role in cembranoid mediated apoptosis to control cancer: Molecular docking and dynamics study

被引：13

作者：

Arpudhamary, V ^{[1
]}

Priya, S. ^{[1
]}

Manzoor, Muhammed A. P. ^{[2
]}

Mubarakali, D. ^{[1
]}

Hemalatha, S. ^{[1
]}

机构：

[1] BS Abdur Rahman Crescent Inst Sci & Technol, Sch Life Sci, Chennai, Tamil Nadu, India

[2] ICAR Indian Inst Spices Res, Distributed Informat Sub Ctr, Kozhikode 673012, Kerala, India

来源：

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY | 2019年 / 22卷

关键词：

Cembranoid; Phytocompounds; Apoptosis; Apoptosis inducing factor1; ESSENTIAL OILS; IN-VITRO; GENE;

D O I：

10.1016/j.bcab.2019.101343

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cancer is a group of diseases characterized by the rapid creation of abnormal cells. Cancer is one of the leading causes of death in humans, affecting millions of people per year. Cembranoids are carbocyclic diterpenes composed of the 14-membered ring, mainly present in the genera Nicotiana and Pinus in plants, soft coral and other organisms. Cembranoids are cytotoxic and inhibit phospholipid metabolism. The present study is focused to evaluate the apoptotic effect of cembranoids in comparison with selective terpenoids from each subclass such as monoterpenoid, diterpenoid, triterpenoid and tetraterpenoid against pro-apoptotic and anti-apoptotic proteins by in silica approach. Molecular docking of terpenoids with apoptotic proteins was assessed using SYBYL-X 1.3 software. The results showed that cembranoid family has good interaction with BAX compared to BC12. This result suggests that cembranoid diterpene lactone can be targeted to Apoptotic-inducing factor 1 (AIF1) to control cancer.

引用

页数：6

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