1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction

被引：32

作者：

Chen, Renjie ^{[1
]}

Liu, Yu ^{[2
]}

Cui, Sunliang ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Life Sci, Sate Key Lab Plant Physiol & Biochem, Hangzhou 310058, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 83期

关键词：

ENANTIOSELECTIVE SYNTHESIS; YNAMIDES; CHEMISTRY; CYCLOADDITION; GENERATION; CATALYSIS; NITRILES; INDOLES; YLIDES; AZIDES;

D O I：

10.1039/c8cc07328g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel 1,4-conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction has been developed. In this protocol, numerous carboxylic acids, ynamides and in situ generated ortho-quinone methides could assemble rapidly to constitute this process for the synthesis of functionalized 3,3-diarylpropanamides with sufficient structural diversity. Furthermore, the products could be transformed to an array of compounds.

引用

页码：11753 / 11756

页数：4

共 67 条

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