1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction

被引：31
|
作者：
Chen, Renjie [1 ]
Liu, Yu [2 ]
Cui, Sunliang [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Life Sci, Sate Key Lab Plant Physiol & Biochem, Hangzhou 310058, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 83期
关键词：
ENANTIOSELECTIVE SYNTHESIS; YNAMIDES; CHEMISTRY; CYCLOADDITION; GENERATION; CATALYSIS; NITRILES; INDOLES; YLIDES; AZIDES;
D O I：
10.1039/c8cc07328g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel 1,4-conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction has been developed. In this protocol, numerous carboxylic acids, ynamides and in situ generated ortho-quinone methides could assemble rapidly to constitute this process for the synthesis of functionalized 3,3-diarylpropanamides with sufficient structural diversity. Furthermore, the products could be transformed to an array of compounds.
引用
收藏
页码：11753 / 11756
页数：4
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