Induction of apoptosis increases expression of non-canonical WNT genes in myeloid leukemia cell lines

被引：0
|
作者：
Sercan, Hakki Ogun
Pehlivan, Melek
Simsek, Ozlenen
Ates, Halil
Sercan, Zeynep [1 ]
机构：
[1] Dokuz Eylul Univ, Fac Med, Dept Biol & Med Genet, TR-35340 Izmir, Turkey
[2] Dokuz Eylul Univ, Fac Med, Dept Hematol Oncol, Izmir, Turkey
来源：
ONCOLOGY REPORTS | 2007年 / 18卷 / 06期
关键词：
Wnt proteins; frizzled receptor; apoptosis; bcr-abl; imatinib;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
With the aim of determining the differential expression of WNT and FZD genes, before and after induction of apoptosis in BCR-ABL positive cells, we treated the myeloid cell line K562 and control cell line HL60 with imatinib mesylate and etoposide, and analyzed relative mRNA expression levels of WNT, FZD and sFRP genes under normal and apoptotic conditions by real-time RT-PCR. We observed marked increase in mRNA levels of FZD4, FZD5, FZD7 and WNT5b, correlating with apoptotic activity and independent of the agent or cell line used. Our results suggest the involvement of non-canonical Wnt signaling in executing programmed cell death in myeloid cell lines.
引用
收藏
页码：1563 / 1569
页数：7
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