RETRACTED: Immunoglobulin G4+ B-Cell Receptor Clones Distinguish Immunoglobulin G4-Related Disease From Primary Sclerosing Cholangitis and Biliary/Pancreatic Malignancies (Retracted Article)

被引：79

作者：

Doorenspleet, Marieke E. ^{[1
,2
]}

Hubers, Lowiek M. ^{[3
,4
]}

Culver, Emma L. ^{[5
,6
]}

Wenniger, Lucas J. Maillette de Buy ^{[3
,4
]}

Klarenbeek, Paul L. ^{[1
,2
]}

Chapman, Roger W. ^{[5
,6
]}

Baas, Frank ^{[2
]}

van de Graaf, Stan F. ^{[3
,4
]}

Verheij, Joanne ^{[7
]}

van Gulik, Thomas M. ^{[8
]}

Barnes, Eleanor ^{[5
,6
]}

Beuers, Ulrich ^{[3
,4
]}

de Vries, Niek ^{[1
]}

机构：

[1] Acad Med Ctr, Amsterdam Rheumatol & Immunol Ctr, Dept Clin Immunol & Rheumatol, Amsterdam, Netherlands

[2] Acad Med Ctr, Dept Genome Anal, Amsterdam, Netherlands

[3] Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[4] Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, Amsterdam, Netherlands

[5] John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford, England

[6] Univ Oxford, Oxford Martin Sch, NDM, Oxford, England

[7] Acad Med Ctr, Dept Pathol, Amsterdam, Netherlands

[8] Acad Med Ctr, Dept Surg, Amsterdam, Netherlands

来源：

HEPATOLOGY | 2016年 / 64卷 / 02期

关键词：

AUTOIMMUNE PANCREATITIS; G4-ASSOCIATED CHOLANGITIS; CLINICAL PROFILE; SERUM IGG4; G4; DIAGNOSIS;

D O I：

10.1002/hep.28568

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) of the biliary tree and pancreas is difficult to distinguish from sclerosing cholangitis and biliary/pancreatic malignancies (CA). An accurate noninvasive test for diagnosis and monitoring of disease activity is lacking. We demonstrate that dominant IgG4(+) B-cell receptor (BCR) clones determined by next-generation sequencing accurately distinguish patients with IgG4-associated cholangitis/autoimmune pancreatitis (n = 34) from those with primary sclerosing cholangitis (n = 17) and CA (n = 17). A novel, more affordable, and widely applicable quantitative polymerase chain reaction (qPCR) protocol analyzing the IgG4/IgG RNA ratio in blood also achieves excellent diagnostic accuracy (n = 125). Moreover, this qPCR test performed better than serum IgG4 levels in sensitivity (94% vs. 86%) and specificity (99% vs. 73%) and correlates with treatment response (n = 20). Conclusions: IgG4(+) BCR clones and IgG4/IgG RNA ratio markedly improve delineation, early diagnosis, and monitoring of IgG4-RD of the biliary tree and pancreas. (Hepatology 2016;64:501-507)

引用

页码：501 / 507

页数：7

共 22 条

[1] EASL Clinical Practice Guidelines: Management of cholestatic liver diseases [J].

Beuers, Ulrich ;

Boberg, Kirsten M. ;

Chapman, Roger W. ;

Chazouilleres, Olivier ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lammert, Frank ;

Pares, Albert ;

Trauner, Michael .

JOURNAL OF HEPATOLOGY, 2009, 51 (02) :237-267

[2] Serum Immunoglobulin G4 and Immunoglobulin G1 for Distinguishing Immunoglobulin G4-Associated Cholangitis From Primary Sclerosing Cholangitis [J].

Boonstra, Kirsten ;

Culver, Emma L. ;

Wenniger, Lucas Maillette de Buy ;

van Heerde, Marianne J. ;

van Erpecum, Karel J. ;

Poen, Alexander C. ;

van Nieuwkerk, Karin M. J. ;

Spanier, B. W. Marcel ;

Witteman, Ben J. M. ;

Tuynman, Hans A. R. E. ;

van Geloven, Nan ;

van Buuren, Henk ;

Chapman, Roger W. ;

Barnes, Eleanor ;

Beuers, Ulrich ;

Ponsioen, Cyriel Y. .

HEPATOLOGY, 2014, 59 (05) :1954-1963

[3] Diagnosis of autoimmune pancreatitis: The Mayo Clinic experience [J].

Chari, Suresh T. ;

Smyrk, Thomas C. ;

Levy, Michael J. ;

Topazian, Mark D. ;

Takahashi, Naoki ;

Zhang, Lizhi ;

Clain, Jonathan E. ;

Pearson, Randall K. ;

Petersen, Bret T. ;

Vege, Santhi Swaroop ;

Farnell, Michael B. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (08) :1010-1016

[4] American Pancreatic Association Practice Guidelines in Chronic Pancreatitis Evidence-Based Report on Diagnostic Guidelines [J].

Conwell, Darwin L. ;

Lee, Linda S. ;

Yadav, Dhiraj ;

Longnecker, Daniel S. ;

Miller, Frank H. ;

Mortele, Koenraad J. ;

Levy, Michael J. ;

Kwon, Richard ;

Lieb, John G. ;

Stevens, Tyler ;

Toskes, Phillip P. ;

Gardner, Timothy B. ;

Gelrud, Andres ;

Wu, Bechien U. ;

Forsmark, Christopher E. ;

Vege, Santhi S. .

PANCREAS, 2014, 43 (08) :1143-1162

[5] Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease [J].

Culver, Emma L. ;

Vermeulen, Ellen ;

Makuch, Mateusz ;

van Leeuwen, Astrid ;

Sadler, Ross ;

Cargi, Tamsin ;

Klenerman, Paul ;

Aalberse, Rob C. ;

van Ham, S. Marieke ;

Barnes, Eleanor ;

Rispens, Theo .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (05) :944-947

[6] Consensus statement on the pathology of IgG4-related disease [J].

Deshpande, Vikram ;

Zen, Yoh ;

Chan, John K. ;

Yi, Eunhee E. ;

Sato, Yasuharu ;

Yoshino, Tadashi ;

Kloeppel, Guenter ;

Heathcote, J. Godfrey ;

Khosroshahi, Arezou ;

Ferry, Judith A. ;

Aalberse, Rob C. ;

Bloch, Donald B. ;

Brugge, William R. ;

Bateman, Adrian C. ;

Carruthers, Mollie N. ;

Chari, Suresh T. ;

Cheuk, Wah ;

Cornell, Lynn D. ;

Fernandez-Del Castillo, Carlos ;

Forcione, David G. ;

Hamilos, Daniel L. ;

Kamisawa, Terumi ;

Kasashima, Satomi ;

Kawa, Shigeyuki ;

Kawano, Mitsuhiro ;

Lauwers, Gregory Y. ;

Masaki, Yasufumi ;

Nakanuma, Yasuni ;

Notohara, Kenji ;

Okazaki, Kazuich ;

Ryu, Ji Kon ;

Saeki, Takako ;

Sahani, Dushyant V. ;

Smyrk, Thomas C. ;

Stone, James R. ;

Takahira, Masayuki ;

Webster, George J. ;

Yamamoto, Motohisa ;

Zamboni, Giuseppe ;

Umehara, Hisanori ;

Stone, John H. .

MODERN PATHOLOGY, 2012, 25 (09) :1181-1192

[7] Frequency and significance of IgG4 immunohistochemical staining in liver explants from patients with primary sclerosing cholangitis [J].

Fischer, Sandra ;

Trivedi, Palak J. ;

Ward, Stephen ;

Greig, Paul D. ;

Therapondos, George ;

Hirschfield, Gideon M. .

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2014, 95 (03) :209-215

[8] Immunoglobulin G4-associated cholangitis: Clinical profile and response to therapy [J].

Ghazale, Amaar ;

Chari, Suresh T. ;

Zhang, Lizhi ;

Smyrk, Thomas C. ;

Takahashi, Naoki ;

Levy, Michael J. ;

Topazian, Mark D. ;

Clain, Jonathan E. ;

Pearson, Randall K. ;

Petersen, Bret T. ;

Vege, Santhi Swaroop ;

Lindor, Keith ;

Farnell, Michael B. .

GASTROENTEROLOGY, 2008, 134 (03) :706-715

[9] Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer [J].

Ghazale, Amaar ;

Chari, Suresh T. ;

Smyrk, Thomas C. ;

Levy, Michael J. ;

Topazian, Mark D. ;

Takahashi, Naoki ;

Clain, Jonathan E. ;

Pearson, Randall K. ;

Pelaez-Luna, Mario ;

Petersen, Bret T. ;

Vege, Santhi Swaroop ;

Farnell, Michael B. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (08) :1646-1653

[10] IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes [J].

Giudicelli, W ;

Chaume, D ;

Lefranc, MP .

NUCLEIC ACIDS RESEARCH, 2005, 33 :D256-D261

← 1 2 3 →