Medial temporal lobe functional connectivity predicts stimulation-induced theta power

被引：41

作者：

Solomon, E. A. ^{[1
]}

Kragel, J. E. ^{[2
]}

Gross, R. ^{[3
]}

Lega, B. ^{[4
]}

Sperling, M. R. ^{[5
]}

Worrell, G. ^{[6
]}

Sheth, S. A. ^{[7
]}

Zaghloul, K. A. ^{[8
]}

Jobst, B. C. ^{[9
]}

Stein, J. M. ^{[10
]}

Das, S. ^{[10
]}

Gorniak, R. ^{[11
]}

Inman, C. S. ^{[3
]}

Seger, S. ^{[4
]}

Rizzuto, D. S. ^{[2
]}

Kahana, M. J. ^{[2
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19146 USA

[2] Univ Penn, Dept Psychol, Philadelphia, PA 19146 USA

[3] Emory Sch Med, Dept Neurosurg, Atlanta, GA 30322 USA

[4] Univ Texas Southwestern, Dept Neurosurg, Dallas, TX 75390 USA

[5] Thomas Jefferson Univ Hosp, Dept Neurol, Philadelphia, PA 19107 USA

[6] Mayo Clin, Dept Physiol & Bioengn, Dept Neurol, Rochester, MN 55905 USA

[7] Baylor Coll Med, Dept Neurosurg, Houston, TX 77030 USA

[8] NIH, Surg Neurol Branch, Bethesda, MD 20814 USA

[9] Dartmouth Med Ctr, Dept Neurol, Lebanon, NH 03756 USA

[10] Hosp Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[11] Thomas Jefferson Univ Hosp, Dept Radiol, Philadelphia, PA 19107 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

美国国家卫生研究院;

关键词：

HUMAN CONNECTOME PROJECT; DIRECT BRAIN-STIMULATION; ELECTRICAL-STIMULATION; IMAGE REGISTRATION; BOLD SIGNAL; MEMORY; SYSTEM; FMRI; MICROSTIMULATION; OSCILLATIONS;

D O I：

10.1038/s41467-018-06876-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5-13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5-8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50-200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.

引用

页数：13

共 56 条

[1] Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain
Avants, B. B.
Epstein, C. L.
Grossman, M.
Gee, J. C.
[J]. MEDICAL IMAGE ANALYSIS, 2008, 12 (01) : 26 - 41
[2] A reproducible evaluation of ANTs similarity metric performance in brain image registration
Avants, Brian B.
Tustison, Nicholas J.
Song, Gang
Cook, Philip A.
Klein, Arno
Gee, James C.
[J]. NEUROIMAGE, 2011, 54 (03) : 2033 - 2044
[3] Betzel R. F., 2017, PREPRINT
[4] Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, Edward T.
Sporns, Olaf
[J]. NATURE REVIEWS NEUROSCIENCE, 2009, 10 (03) : 186 - 198
[5] Memory, navigation and theta rhythm in the hippocampal-entorhinal system
Buzsaki, Gyoergy
Moser, Edvard I.
[J]. NATURE NEUROSCIENCE, 2013, 16 (02) : 130 - 138
[6] Mechanisms and Functions of Theta Rhythms
Colgin, Laura Lee
[J]. ANNUAL REVIEW OF NEUROSCIENCE, VOL 36, 2013, 36 : 295 - 312
[7] Brain oscillations and memory
Duezel, Emrah
Penny, Will D.
Burgess, Neil
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2010, 20 (02) : 143 - 149
[8] Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
Ezzyat, Youssef
Wanda, Paul A.
Levy, Deborah F.
Kadel, Allison
Aka, Ada
Pedisich, Isaac
Sperling, Michael R.
Sharan, Ashwini D.
Lega, Bradley C.
Burks, Alexis
Gross, Robert E.
Inman, Cory S.
Jobst, Barbara C.
Gorenstein, Mark A.
Davis, Kathryn A.
Worrell, Gregory A.
Kucewicz, Michal T.
Stein, Joel M.
Gorniak, Richard
Das, Sandhitsu R.
Rizzuto, Daniel S.
Kahana, Michael J.
[J]. NATURE COMMUNICATIONS, 2018, 9
[9] Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans
Ezzyat, Youssef
Kragel, James E.
Burke, John F.
Levy, Deborah F.
Lyalenko, Anastasia
Wanda, Paul
O'Sullivan, Logan
Hurley, Katherine B.
Busygin, Stanislav
Pedisich, Isaac
Sperling, Michael R.
Worrell, Gregory A.
Kucewicz, Michal T.
Davis, Kathryn A.
Lucas, Timothy H.
Inman, Cory S.
Lega, Bradley C.
Jobst, Barbara C.
Sheth, Sameer A.
Zaghloul, Kareem
Jutras, Michael J.
Stein, Joel M.
Das, Sandhitsu R.
Gorniak, Richard
Rizzuto, Daniel S.
Kahana, Michael J.
[J]. CURRENT BIOLOGY, 2017, 27 (09) : 1251 - 1258
[10] Human memory formation is accompanied by rhinal-hippocampal coupling and decoupling
Fell, J
Klaver, P
Lehnertz, K
Grunwald, T
Schaller, C
Elger, CE
Fernández, G
[J]. NATURE NEUROSCIENCE, 2001, 4 (12) : 1259 - 1264

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