High level expression of stag1/pmepa1 in an androgen-independent prostate cancer pc3 subclone

被引：14

作者：

Hirokawa, Yoshifumi S.

Takagi, Akimitsu

Uchida, Katsunori

Kozuka, Yuji

Yoneda, Misao

Watanabe, Masatoshi

Shiraishi, Taizo

机构：

[1] Mie Univ, Fac Med, Dept Pathol & Oncol, Inst Mol & Expt Med,Grad Sch Med, Tsu, Mie 5148507, Japan

[2] Yokohama Natl Univ, Lab Med Engn, Div Mat Sci & Chem Engn, Grad Sch Engn, Yokohama, Kanagawa 240, Japan

来源：

CELLULAR & MOLECULAR BIOLOGY LETTERS | 2007年 / 12卷 / 03期

关键词：

STAG1/PMEPA1; IL-8; E-cadherin; prostate cancer cell line;

D O I：

10.2478/s11658-007-0009-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

引用

页码：370 / 377

页数：8

共 14 条

[1]

Brunschwig EB, 2003, CANCER RES, V63, P1568

[2]

Cheng L, 1996, AM J PATHOL, V148, P1375

[3] EGF- and cell-cycle-regulated STAG1/PMEPA1 ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer [J].

Giannini, G ;

Ambrosini, MI ;

Di Marcotullio, L ;

Cerignoli, F ;

Zani, M ;

MacKay, AR ;

Screpanti, I ;

Frati, L ;

Gulino, A .

MOLECULAR CARCINOGENESIS, 2003, 38 (04) :188-200

[4]

Inoue K, 2000, CANCER RES, V60, P2290

[5] Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice [J].

Kim, SJ ;

Uehara, H ;

Karashima, T ;

Mccarty, M ;

Shih, N ;

Fidler, IJ .

NEOPLASIA, 2001, 3 (01) :33-42

[6]

Micka KA, 1996, J FORENSIC SCI, V41, P582

[7] Distinct CXC chemokines mediate tumorigenicity of prostate cancer cells [J].

Moore, BB ;

Arenberg, DA ;

Stoy, K ;

Morgan, T ;

Addison, CL ;

Morris, SB ;

Glass, M ;

Wilke, C ;

Xue, YY ;

Sitterding, S ;

Kunkel, SL ;

Burdick, MD ;

Strieter, RM .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (05) :1503-1512

[8] Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer [J].

Murphy, C ;

McGurk, M ;

Pettigrew, J ;

Santinelli, A ;

Mazzucchelli, R ;

Johnston, PG ;

Montironi, R ;

Waugh, DJJ .

CLINICAL CANCER RESEARCH, 2005, 11 (11) :4117-4127

[9] EXPRESSION OF CELLULAR ADHESION MOLECULES ON HUMAN PROSTATE TUMOR-CELL LINES [J].

ROKHLIN, OW ;

COHEN, MB .

PROSTATE, 1995, 26 (04) :205-212

[10] Characterization of TGF-β-regulated interleukin-8 expression in human prostate cancer cells [J].

Shan Lu ;

Dong, Zhongyun .

PROSTATE, 2006, 66 (09) :996-1004

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