Neoadjuvant chemotherapy with a combination of docetaxel, cisplatin, fluorouracil, and leucovorin in nonresectable advanced gastric cancer: a short communication

被引：2
作者：
Ma, Yanlei [1 ]
Qin, Huanlong [1 ]
Zheng, Qi [1 ]
Wang, Yu [1 ]
Wang, Zhiguo [1 ]
Yang, Zhe [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Peoples Hosp Affiliated 6, Dept Surg, Shanghai 200233, Peoples R China
来源：
MEDICAL ONCOLOGY | 2010年 / 27卷 / 04期
关键词：
Neoadjuvant chemotherapy; Nonresectable advanced gastric cancer; Docetaxel; Cisplatin; Fluorouracil; Leucovorin; PHASE-II; PLUS FLUOROURACIL; RANDOMIZED-TRIAL; 1ST-LINE THERAPY; D2; GASTRECTOMY; CARCINOMA; ADENOCARCINOMA; SURVIVAL; STRATEGIES; ETOPOSIDE;
D O I：
10.1007/s12032-009-9340-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to evaluate the efficacy and toxicity of docetaxel (TAX), cisplatin (CDDP), and fluorouracil (5-FU) plus leucovorin (CF) as the neoadjuvant chemotherapy (NACT) regimens in the treatment of nonresectable advanced gastric cancer. Twelve patients with nonresectable advanced gastric cancer were treated with NACT regimens consisted of docetaxel, cisplatin, fluorouracil, plus leucovorin before operation. Nine of the 12 patients were downstaged and 8 were radically operated after the end of the NACT. The overall response rate was 75% with 8.3% complete response and 66.7% partial response, and the ascites disappeared in 63.6%. The most common toxicities were bone marrow suppression, nausea, vomiting, alopecia, and heptoses. The toxicities were recoverable after symptomatic treatment. The results confirmed that the combination of docetaxel, cisplatin, fluorouracil plus leucovorin (CF) is a very effective and well-tolerated regimen as NACT for the patients with nonresectable advanced gastric cancer.
引用
收藏
页码：1089 / 1095
页数：7
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