Extracellular calcium and cAMP: Second messengers as "third messengers"?

被引:79
作者
Hofer, Aldebaran M. [1 ]
Lefkimmiatis, Konstantinos [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Surg, Cambridge, MA 02138 USA
关键词
D O I
10.1152/physiol.00019.2007
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Calcium and cyclic AMP are familiar second messengers that typically become elevated inside cells on activation of cell surface receptors. This article will explore emerging evidence that transport of these signaling molecules across the plasma membrane allows them to be recycled as "third messengers," extending their ability to convey information in a domain outside the cell.
引用
收藏
页码:320 / 327
页数:8
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