Chemical characterization and antihyperglycaemic effects of polyphenol enriched longan (Dimocarpus longan Lour.) pericarp extracts

被引：37
|
作者：
Li, Liya [1 ]
Xu, Jialin [2 ]
Mu, Yu [1 ]
Han, Li [1 ]
Liu, Ruohan [1 ]
Cai, Yaping [1 ]
Huang, Xueshi [1 ]
机构：
[1] Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China
[2] Northeastern Univ, Coll Life & Hlth Sci, Inst Biochem & Mol Biol, Shenyang 110819, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2015年 / 13卷
基金：
美国国家科学基金会;
关键词：
Anti-hyperglycaemic; alpha-Glucosidase; Dimocarpus longan Lour; Polyphenol; Chemical composition; ALPHA-AMYLASE; ELLAGIC ACID; ANTIOXIDANT ACTIVITIES; DIETARY POLYPHENOLS; GLUCOSE-UPTAKE; PPAR-GAMMA; TRANSLOCATION; POMEGRANATE; INHIBITION; IDENTIFICATION;
D O I：
10.1016/j.jff.2015.01.006
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The chemical composition and anti-hyperglycaemic effects of polyphenol-enriched Longan pericarp extracts (LPE) were investigated in the present study. The phenolic profile of LPE was determined by HPLC-DAD/MS analysis. Nine phenolics were identified, and of these, three major components were quantified by LC-MS/MS. Anti-hyperglycaemic assays demonstrate that LPE (polyphenol content ca. 37.8 g gallic acid equivalents/100 g) inhibit a-glucosidase (IC50 = 11.68 +/- 0.44 mu g/mL) in vitro and decrease blood glucose content in mice (P < 0.05) upon sucrose challenge. In addition, LPE improves mouse glucose tolerance following 5 days of treatment by oral gavage (10 mg/kg body weight), which may be due to the increased gene expression associated with insulin signalling pathway, such as insulin receptor substrate-1, peroxisome proliferator-activated receptor gamma and glucose transporter 4. Overall, our results suggest that LPE could impact carbohydrate metabolism and enhance insulin sensitivity and may serve as a potential anti-hyperglycaemic agent in diabetes care. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：314 / 322
页数：9
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