Solubility study of carvedilol in the aqueous mixtures of a choline chloride/propylene glycol deep eutectic solvent

被引：17

作者：

Sayad, Taher ^{[1
,2
,3
]}

Poturcu, Kader ^{[2
,3
,4
]}

Moradi, Milad ^{[1
,2
,3
]}

Rahimpour, Elaheh ^{[2
,3
,5
]}

Zhao, Hongkun ^{[6
]}

Jouyban, Abolghasem ^{[2
,3
,7
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Student Res Comm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] Suleyman Demirel Univ, Arts & Sci Fac, Dept Chem, Isparta, Turkey

[5] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran

[6] YangZhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[7] Near East Univ, Fac Pharm, POB 99138,Mersin 10, Nicosia, North Cyprus, Turkey

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 342卷

关键词：

Carvedilol; Solubility; Deep eutectic solvent; Cosolvency; Mathematical modeling; Thermodynamic parameters; PREDICTING DRUG SOLUBILITY; PROPYLENE-GLYCOL; MODELS; CYCLODEXTRIN; DELIVERY;

D O I：

10.1016/j.molliq.2021.117537

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Solubility behavior of a poorly soluble drug (carvedilol) has been studied in the aqueous mixtures of a deep eutectic solvent composed of choline chloride and propylene glycol at different temperatures (293.15-313.15) K. The obtained solubility data are correlated using some of the well-known cosolvency models such as the van't Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models. The accuracy of these mathematical models is investigated with the mean relative deviations of the back calculated solubility data. The apparent thermodynamic properties (i.e. Gibbs energy, enthalpy and entropy) of carvedilol in the investigated mixtures are also calculated with the van't Hoff and Gibbs equations at Thm. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：7

共 40 条

[1] Laminated sponges as challenging solid hydrophilic matrices for the buccal delivery of carvedilol microemulsion systems: Development and proof of concept via mucoadhesion and pharmacokinetic assessments in healthy human volunteers [J].