Augmented immune responses to a booster dose of oral cholera vaccine in Bangladeshi children less than 5 years of age: Revaccination after an interval of over three years of primary vaccination with a single dose of vaccine

被引：10

作者：

Chowdhury, Fahima ^{[1
]}

Bhuiyan, Taufiqur Rahman ^{[1
]}

Akter, Afroza ^{[1
]}

Bhuiyan, Md Saruar ^{[1
]}

Khan, Ashraful Islam ^{[1
]}

Tauheed, Imam ^{[1
]}

Ahmed, Tasnuva ^{[1
]}

Ferdous, Jannatul ^{[1
]}

Dash, Pinki ^{[1
]}

Basher, Salima Raiyan ^{[1
]}

Al Hakim ^{[1
]}

Lynch, Julia ^{[2
]}

Kim, Jerome H. ^{[2
]}

Excler, Jean-Louis ^{[2
]}

Kim, Deok Ryun ^{[2
]}

Clemens, John D. ^{[1
,3
,4
]}

Qadri, Firdausi ^{[1
]}

机构：

[1] Int Ctr Diarrhoeal Dis Res, 68 Shaheed Tajuddin Ahmed Sarani, Dhaka 1212, Bangladesh

[2] Int Vaccine Inst, Seoul, South Korea

[3] UCLA, Fielding Sch Publ Hlth, Los Angeles, CA USA

[4] Korea Univ, Sch Med, Seoul, South Korea

来源：

VACCINE | 2020年 / 38卷 / 07期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

Oral Cholera Vaccine (OCV); Augmented immune response; Booster dose; Primary dose; Shanchol; ANTIBODY-SECRETING CELL; SUBUNIT-WHOLE-CELL; VIBRIOCIDAL ANTIBODY; DOUBLE-BLIND; B-CELLS; IMMUNOGENICITY; ANTIGEN; SAFETY; PROTECTION; INFECTION;

D O I：

10.1016/j.vaccine.2019.12.034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have earlier reported that a single dose of oral cholera vaccine (OCV) is protective in adults and children >= 5 years of age and sustained for 2 years. We enrolled participants (n = 240) from this study, between March-September 2017, over 3 years after receiving a primary single dose. Immune responses were measured in placebo group (Primary Immunization group: PI) and compared with those who received a single dose (Booster Immunization group: BI). The children were 4 to <5 years, 5 to <18 years and adults >18 years. Blood was collected at day 0 (before vaccination) and after receiving 1st and 2nd doses of OCV. Overall, the BI and PI groups showed vibriocidal antibody response after 1st and 2nd dose of vaccination in all age groups to V. cholerae O1 and O139. Young children in the BI group showed significantly higher vibriocidal antibody response two weeks after receiving the first dose as compared to PI group to LPS. Elevated plasma IgA responses to LPS after the first dose were observed among the BI group compared to the PI group among the young children. Mucosal antibody responses measured in fecal extracts showed similar increases as that of vibriocidal and LPS responses in the BI group. These results suggest a single boosting dose of OCV generated immune response in primed population >5 years of age who had earlier received OCV. However, young children who had received OCV earlier, boosting after a single dose, resulted in increased immune responses compared to the PI group. Further studies are needed to assess protection obtained from different strategies, especially for young children and to determine the numbers of primary and booster doses needed. In addition, more information is needed regarding the optimum interval between primary and booster doses to plan future interventions for cholera control. (C) 2019 The Authors. Published by Elsevier Ltd.

引用

页码：1753 / 1761

页数：9

共 36 条

[1]

Abba K, 2010, COCHRANE DB SYST REV, P7

[2]

Åhrén C, 1998, INFECT IMMUN, V66, P3311

[3] Kinetics of antibody-secreting cell and fecal IgA responses after oral cholera vaccination in different age groups in a cholera endemic country [J].

Akhtar, Marjahan ;

Qadri, Firdausi ;

Bhuiyan, Taufiqur R. ;

Akter, Sarmin ;

Rafique, Tanzeem A. ;

Khan, Arifuzzaman ;

Islam, Laila N. ;

Saha, Amit ;

Svennerholm, Ann-Mari ;

Lundgren, Anna .

VACCINE, 2017, 35 (02) :321-328

[4]

Aktar A, 2016, CLIN VACCINE IMMUNOL

[5] Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh [J].

Aktar, Amena ;

Rahman, M. Arifur ;

Afrin, Sadia ;

Akter, Aklima ;

Uddin, Taher ;

Yasmin, Tahirah ;

Sami, Md. Israk Nur ;

Dash, Pinki ;

Jahan, Sultana Rownok ;

Chowdhury, Fahima ;

Khan, Ashraful I. ;

LaRocque, Regina C. ;

Charles, Richelle C. ;

Bhuiyan, Taufiqur Rahman ;

Mandlik, Anjali ;

Kelly, Meagan ;

Kovac, Pavol ;

Xu, Peng ;

Calderwood, Stephen B. ;

Harris, Jason B. ;

Qadri, Firdausi ;

Ryan, Edward T. .

PLOS NEGLECTED TROPICAL DISEASES, 2018, 12 (04)

[6]

Alam MM, 2011, CLIN VACCINE IMMUNOL

[7] Supplementation with zinc, but not vitamin A, improves seroconversion to vibriocidal antibody in children given an oral cholera vaccine [J].

Albert, MJ ;

Qadri, F ;

Wahed, MA ;

Ahmed, T ;

Rahman, ASMH ;

Ahmed, F ;

Bhuiyan, NA ;

Zaman, K ;

Baqui, AH ;

Clemens, JD ;

Black, RE .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (06) :909-913

[8] Natural Cholera Infection-Derived Immunity in an Endemic Setting [J].

Ali, Mohammad ;

Emch, Michael ;

Park, Jin Kyung ;

Yunus, Mohammad ;

Clemens, John .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (06) :912-918

[9]

[Anonymous], 2017, Wkly Epidemiol Rec, V92, P477

[10] The Impact of a One-Dose versus Two-Dose Oral Cholera Vaccine Regimen in Outbreak Settings: A Modeling Study [J].

Azman, Andrew S. ;

Luquero, Francisco J. ;

Ciglenecki, Iza ;

Grais, Rebecca F. ;

Sack, David A. ;

Lessler, Justin .

PLOS MEDICINE, 2015, 12 (08)

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