Carbon monoxide regulates cerebral blood flow in epileptic seizures but not in hypercapnia

被引：35

作者：

Montécot, C ^{[1
]}

Seylaz, J ^{[1
]}

Pinard, E ^{[1
]}

机构：

[1] Univ Paris 07, CNRS, UPR 646,IFR 6, Lab Rech Cerebrovasc, F-75010 Paris, France

来源：

NEUROREPORT | 1998年 / 9卷 / 10期

关键词：

cerebral blood flow; carbon monoxide; epilepsy; hypercapnia; kainate;

D O I：

10.1097/00001756-199807130-00035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CARBON monoxide (CO) is an endogenously produced gas sharing many properties with nitric oxide (NO), notably activating soluble guanylate cyclase and relaxing blood vessels. The brain can generate high quantities of CO from a constitutive enzyme, haem oxygenase (HO-2). To determine whether CO is involved in the regulatory mechanisms of cerebral blood flow (CBF), two conditions associated with a reproducible CBF increase were studied in rats: epileptic seizures induced by kainate, and hypercapnia. The HO inhibitor tin protoporphyrin (Sn-PP) did not modify the basal level of CBF, significantly reduced the increase in CBF during status epilepticus, and did not affect the cerebrovascular response to hypercapnia. It is concluded that CO participates in the regulation of CBF in specific conditions, notably those associated with glutamate release. NeuroReport 9: 2341-2346 (C) 1998 Rapid Science Ltd.

引用

页码：2341 / 2346

页数：6

共 50 条

[41] Absence seizures induce a decrease in cerebral blood flow: Human and animal data [J].

Nehlig, A ;

Vergnes, M ;

Waydelich, R ;

Hirsch, E ;

Charbonne, R ;

Marescaux, C ;

Seylaz, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (01) :147-155

[42] Dynamic variations of local cerebral blood flow in maximal electroshock seizures in the rat [J].

André, V ;

Henry, D ;

Nehlig, A .

EPILEPSIA, 2002, 43 (10) :1120-1128

[43] Regional variability of cerebral blood oxygenation response to hypercapnia [J].

Kastrup, A ;

Krüger, G ;

Glover, GH ;

Neumann-Haefelin, T ;

Moseley, ME .

NEUROIMAGE, 1999, 10 (06) :675-681

[44] Frequency dependence of local cerebral blood flow induced by somatosensory hind paw stimulation in rat under normo- and hypercapnia [J].

Bakalova, R ;

Matsuura, T ;

Kanno, I .

JAPANESE JOURNAL OF PHYSIOLOGY, 2001, 51 (02) :201-208

[45] The vasorelaxation of cerebral arteries by carbon monoxide [J].

Komuro, T ;

Borsody, MK ;

Ono, S ;

Marton, LS ;

Weir, BK ;

Zhang, ZD ;

Paik, E ;

Macdonald, RL .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2001, 226 (09) :860-865

[46] Control of Cerebral Blood Flow by Blood Gases [J].

Duffin, James ;

Mikulis, David J. ;

Fisher, Joseph A. .

FRONTIERS IN PHYSIOLOGY, 2021, 12

[47] Spatial flow-volume dissociation of the cerebral microcirculatory response to mild hypercapnia [J].

Hutchinson, Elizabeth B. ;

Stefanovic, Bojana ;

Koretsky, Alan P. ;

Silva, Afonso C. .

NEUROIMAGE, 2006, 32 (02) :520-530

[48] Epileptic Seizure Detection and Prediction Based on Continuous Cerebral Blood Flow Monitoring - a Review [J].

Tewolde, Senay ;

Oommen, Kalarickal ;

Lie, Donald Y. C. ;

Zhang, Yuanlin ;

Chyu, Ming-Chien .

JOURNAL OF HEALTHCARE ENGINEERING, 2015, 6 (02) :159-178

[49] PHRENIC BLOOD-FLOW IN HYPOXIA AND HYPERCAPNIA [J].

SANOTSKAYA, NV ;

MATSIEVSKII, DD ;

ALEINIKOV, SO .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1992, 114 (12) :1758-1764

[50] LOCAL CEREBRAL BLOOD-FLOW RESPONSES IN RATS TO HYPERCAPNIA AND HYPOXIA IN THE ROSTRAL VENTROLATERAL MEDULLA AND IN THE CORTEX [J].

SATO, A ;

TRZEBSKI, A ;

ZHOU, W .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1992, 41 (1-2) :79-86

← 1 2 3 4 5 →