Carbon monoxide regulates cerebral blood flow in epileptic seizures but not in hypercapnia

被引：35

作者：

Montécot, C ^{[1
]}

Seylaz, J ^{[1
]}

Pinard, E ^{[1
]}

机构：

[1] Univ Paris 07, CNRS, UPR 646,IFR 6, Lab Rech Cerebrovasc, F-75010 Paris, France

来源：

NEUROREPORT | 1998年 / 9卷 / 10期

关键词：

cerebral blood flow; carbon monoxide; epilepsy; hypercapnia; kainate;

D O I：

10.1097/00001756-199807130-00035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CARBON monoxide (CO) is an endogenously produced gas sharing many properties with nitric oxide (NO), notably activating soluble guanylate cyclase and relaxing blood vessels. The brain can generate high quantities of CO from a constitutive enzyme, haem oxygenase (HO-2). To determine whether CO is involved in the regulatory mechanisms of cerebral blood flow (CBF), two conditions associated with a reproducible CBF increase were studied in rats: epileptic seizures induced by kainate, and hypercapnia. The HO inhibitor tin protoporphyrin (Sn-PP) did not modify the basal level of CBF, significantly reduced the increase in CBF during status epilepticus, and did not affect the cerebrovascular response to hypercapnia. It is concluded that CO participates in the regulation of CBF in specific conditions, notably those associated with glutamate release. NeuroReport 9: 2341-2346 (C) 1998 Rapid Science Ltd.

引用

页码：2341 / 2346

页数：6

共 50 条

[31] Carbon monoxide regulates blood pressure cooperatively with nitric oxide in hypertensive rats [J].

Ushiyama, M ;

Morita, T ;

Katayama, S .

HEART AND VESSELS, 2002, 16 (05) :189-195

[32] Carbon monoxide regulates blood pressure cooperatively with nitric oxide in hypertensive rats [J].

Masayuki Ushiyama ;

T. Morita ;

Shigehiro Katayama .

Heart and Vessels, 2002, 16 :189-195

[33] Regional cerebral blood flow and glucose utilization in spontaneously epileptic EL mice [J].

Hosokawa, C ;

Ochi, H ;

Yamagami, S ;

Yamada, R .

JOURNAL OF NUCLEAR MEDICINE, 1997, 38 (04) :613-616

[34] Ventilatory response to carbon monoxide during exercise in hypoxia and hypercapnia [J].

Crocker, George H. ;

Kwon, Jenny ;

Kass, Philip H. ;

Jones, James H. .

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2017, 246 :86-91

[35] Epileptic seizures increase circulating endothelial cells in peripheral blood as early indicators of cerebral vascular damage [J].

Parfenova, Helena ;

Leffler, Charles W. ;

Tcheranova, Dilyara ;

Basuroy, Shyamali ;

Zimmermann, Aliz .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 298 (06) :H1687-H1698

[36] Cerebral blood flow regulates iron overload in the cerebral nuclei of hemodialysis patients with anemia [J].

Wang, Huiying ;

Chai, Chao ;

Wu, Gemuer ;

Li, Jinping ;

Zhao, Chenxi ;

Fu, Dingwei ;

Zhang, Shengtong ;

Wang, Huapeng ;

Wang, Beini ;

Zhu, Jinxia ;

Shen, Wen ;

Xia, Shuang .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2023, 43 (05) :749-762

[37] Vasodilation Mechanism of Cerebral Microvessels Induced by Neural Activation under High Baseline Cerebral Blood Flow Level Results from Hypercapnia in Awake Mice [J].

Nishino, Asuka ;

Takuwa, Hiroyuki ;

Urushihata, Takuya ;

Ito, Hiroshi ;

Ikoma, Yoko ;

Matsuura, Tetsuya .

MICROCIRCULATION, 2015, 22 (08) :744-752

[38] Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate [J].

Montecot, C ;

Borredon, J ;

Seylaz, J ;

Pinard, E .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (01) :94-99

[39] Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis: A hypercapnia MRI study [J].

Marshall, Olga ;

Chawla, Sanjeev ;

Lu, Hanzhang ;

Pape, Louise ;

Ge, Yulin .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 (12) :2087-2095

[40] Early and late epileptic seizures following cerebral hemisphere ischemia [J].

Marrero, C ;

Diez, E ;

Ivanez, V ;

Barreiro, P .

REVISTA DE NEUROLOGIA, 1998, 27 (158) :676-681

← 1 2 3 4 5 →