Acute Erythroleukemia (AML-M6) in one-year-old boy: a case report

被引:2
作者
Prabawa, I. Putu Yuda [1 ]
Mahartini, Ni Nyoman [2 ]
Herawati, Sianny [2 ]
Mulyantari, Ni Kadek [2 ]
机构
[1] Univ Udayana, Prof dr IGNG Ngoerah Hosp, Clin Pathol Residency Educ Program, Fac Med, Denpasar, Bali, Indonesia
[2] Univ Udayana, Prof dr IGNG Ngoerah Hosp, Dept Clin Pathol, Fac Med, Denpasar, Bali, Indonesia
关键词
Acute Erythroleukemia; Bone Marrow Aspiration; Pediatric; AML; -M6; ACUTE MYELOID-LEUKEMIA; MYELODYSPLASTIC SYNDROME; CLASSIFICATION; CHILDHOOD;
D O I
10.15562/bmj.v11i3.3803
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Acute Erythroleukemia (AML-M6) is a rare case with approximately 3-4% of all Acute Myeloid Leukemia (AML) cases. AML-M6 is less common in the pediatric population, with an incidence of <1% of all pediatric leukemia cases. This case study aims to evaluate Acute Erythroleukemia (AML-M6) in a one-year-old boy at Prof. dr. IGNG Ngoerah Denpasar. Case Presentation: A one-year-old boy with clinical manifestations of fluctuating fever for a month, paleness, bleeding gums, bruising all over his body, swelling of both eyelids and splenomegaly. Peripheral Blood Smear (PBS) examination revealed bicytopenia with moderate normochromic normocytic anemia, severe thrombocytopenia and leukocytosis. A hypercellular picture was obtained from the examination of Bone Marrow Aspiration (BMA) with an increase in erythroblast activity of 74%, proerythroblast at 50% and normal myeloblasts activity at 10%. The patient was diagnosed with Acute Erythroleukemia (AML-M6). The patient died on day 16 of treatment. Conclusion: Based on the examination results, it was concluded that the patient was diagnosed with AML-M6 according to the PBS and BMA evaluation.
引用
收藏
页码:1420 / 1425
页数:6
相关论文
共 17 条
[1]   Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study [J].
Almeida, Antonio M. ;
Prebet, Thomas ;
Itzykson, Raphael ;
Ramos, Fernando ;
Al-Ali, Haifa ;
Shammo, Jamile ;
Pinto, Ricardo ;
Maurillo, Luca ;
Wetzel, Jaime ;
Musto, Pellegrino ;
Van De Loosdrecht, Arjan A. ;
Costa, Maria Joao ;
Esteves, Susana ;
Burgstaller, Sonja ;
Stauder, Reinhard ;
Autzinger, Eva M. ;
Lang, Alois ;
Krippl, Peter ;
Geissler, Dietmar ;
Francisco Falantes, Jose ;
Pedro, Carmen ;
Bargay, Joan ;
Deben, Guillermo ;
Garrido, Ana ;
Bonanad, Santiago ;
Diez-Campelo, Maria ;
Thepot, Sylvain ;
Ades, Lionel ;
Sperr, Wolfgang R. ;
Valent, Peter ;
Fenaux, Pierre ;
Sekeres, Mikkael A. ;
Greil, Richard ;
Pleyer, Lisa .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (04)
[2]   The 2016 WHO classification of acute myeloid leukemia: What the practicing clinician needs to know [J].
Arber, Daniel A. .
SEMINARS IN HEMATOLOGY, 2019, 56 (02) :90-95
[3]   Revisiting erythroleukemia [J].
Arber, Daniel A. .
CURRENT OPINION IN HEMATOLOGY, 2017, 24 (02) :146-151
[4]   Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: Report from the children's oncology group [J].
Barnard, Dorothy R. ;
Alonzo, Todd A. ;
Gerbing, Robert B. ;
Lange, Beverly ;
Woods, William G. .
PEDIATRIC BLOOD & CANCER, 2007, 49 (01) :17-22
[5]   PROPOSALS FOR CLASSIFICATION OF ACUTE LEUKEMIAS [J].
BENNETT, JM ;
CATOVSKY, D ;
DANIEL, MT ;
FLANDRIN, G ;
GALTON, DAG ;
GRALNICK, HR ;
SULTAN, C .
BRITISH JOURNAL OF HAEMATOLOGY, 1976, 33 (04) :451-&
[6]   PROPOSED REVISED CRITERIA FOR THE CLASSIFICATION OF ACUTE MYELOID-LEUKEMIA - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].
BENNETT, JM ;
CATOVSKY, D ;
DANIEL, MT ;
FLANDRIN, G ;
GALTON, DAG ;
GRALNICK, HR ;
SULTAN, C .
ANNALS OF INTERNAL MEDICINE, 1985, 103 (04) :620-625
[7]  
Day DS, 1997, ANN CLIN LAB SCI, V27, P142
[8]   Pure erythroid leukemia [J].
Escribano Serrat, Silvia ;
Calo Perez, Aida .
BLOOD, 2021, 137 (19) :2709-2709
[9]   Acute erythremic myelosis (true erythroleukaemia): a variant of AML FAB-M6 [J].
Hasserjian, RP ;
Howard, J ;
Wood, A ;
Henry, K ;
Bain, B .
JOURNAL OF CLINICAL PATHOLOGY, 2001, 54 (03) :205-209
[10]  
Kesamneni R, 2016, J APPL HEMATOLOGY, V7, P111