The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

被引:35
作者
Argenziano, Maura [1 ]
Tortora, Chiara [2 ]
Bellini, Giulia [1 ]
Di Paola, Alessandra [1 ]
Punzo, Francesca [1 ]
Rossi, Francesca [2 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Expt Med, I-80138 Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Women Child & Gen & Specialized Surg, I-80138 Naples, Italy
关键词
CB1; receptor; CB2; endocannabinoid system; inflammation; immune regulation; CANNABINOID RECEPTOR 2; MESENCHYMAL STEM-CELLS; ENDOTHELIAL DYSFUNCTION; RHEUMATOID-ARTHRITIS; INSULIN SENSITIVITY; MEDIATED DISEASES; CELIAC-DISEASE; Q63R VARIANT; FOOD-INTAKE; T-CELLS;
D O I
10.3390/ijms20235875
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. CB2, to a great extent, and CB1, to a lesser extent, are involved in regulating the immune response. They also regulate the inflammatory processes by inhibiting pro-inflammatory mediator release and immune cell proliferation. This review provides an overview on the role of the endocannabinoid system with a major focus on cannabinoid receptors in the pathogenesis and onset of inflammatory and autoimmune pediatric diseases, such as immune thrombocytopenia, juvenile idiopathic arthritis, inflammatory bowel disease, celiac disease, obesity, neuroinflammatory diseases, and type 1 diabetes mellitus. These disorders have a high social impact and represent a burden for the healthcare system, hence the importance of individuating more innovative and effective treatments. The endocannabinoid system could address this need, representing a possible new diagnostic marker and therapeutic target.
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页数:15
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