Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent

被引：1283

作者：

Linnen, J

Wages, J

ZhangKeck, ZY

Fry, KE

Krawczynski, KZ

Alter, H

Koonin, E

Gallagher, M

Alter, M

Hadziyannis, S

Karayiannis, P

Fung, K

Nakatsuji, Y

Shih, JWK

Young, L

Piatak, M

Hoover, C

Fernandez, J

Chen, S

Zou, JC

Morris, T

Hyams, KC

Ismay, S

Lifson, JD

Hess, G

Foung, SKH

Thomas, H

Bradley, D

Margolis, H

Kim, JP

机构：

[1] GENELABS TECHNOL,REDWOOD CITY,CA 94063

[2] CTR DIS CONTROL & PREVENT,HEPATITIS BRANCH,ATLANTA,GA 30333

[3] NIH,DEPT TRANSFUS MED,BETHESDA,MD 20205

[4] NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894

[5] HIPPOKRATEION HOSP,ACAD DEPT MED,ATHENS,GREECE

[6] ST MARYS HOSP,SCH MED,DEPT MED,LONDON,ENGLAND

[7] USN,MED RES INST,ROCKVILLE,MD 20852

[8] NEW S WALES RED CROSS BLOOD TRANSFUS SERV,SYDNEY,NSW,AUSTRALIA

[9] BOEHRINGER MANNHEIM GMBH,D-68305 MANNHEIM,GERMANY

来源：

SCIENCE | 1996年 / 271卷 / 5248期

关键词：

D O I：

10.1126/science.271.5248.505

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

引用

页码：505 / 508

页数：4