Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent

被引：1283
作者：
Linnen, J
Wages, J
ZhangKeck, ZY
Fry, KE
Krawczynski, KZ
Alter, H
Koonin, E
Gallagher, M
Alter, M
Hadziyannis, S
Karayiannis, P
Fung, K
Nakatsuji, Y
Shih, JWK
Young, L
Piatak, M
Hoover, C
Fernandez, J
Chen, S
Zou, JC
Morris, T
Hyams, KC
Ismay, S
Lifson, JD
Hess, G
Foung, SKH
Thomas, H
Bradley, D
Margolis, H
Kim, JP
机构：
[1] GENELABS TECHNOL,REDWOOD CITY,CA 94063
[2] CTR DIS CONTROL & PREVENT,HEPATITIS BRANCH,ATLANTA,GA 30333
[3] NIH,DEPT TRANSFUS MED,BETHESDA,MD 20205
[4] NATL LIB MED,NATL CTR BIOTECHNOL INFORMAT,BETHESDA,MD 20894
[5] HIPPOKRATEION HOSP,ACAD DEPT MED,ATHENS,GREECE
[6] ST MARYS HOSP,SCH MED,DEPT MED,LONDON,ENGLAND
[7] USN,MED RES INST,ROCKVILLE,MD 20852
[8] NEW S WALES RED CROSS BLOOD TRANSFUS SERV,SYDNEY,NSW,AUSTRALIA
[9] BOEHRINGER MANNHEIM GMBH,D-68305 MANNHEIM,GERMANY
来源：
SCIENCE | 1996年 / 271卷 / 5248期
关键词：
D O I：
10.1126/science.271.5248.505
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
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收藏
页码：505 / 508
页数：4
相关论文
共 31 条
  • [1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS
    ALTER, HJ
    PURCELL, RH
    SHIH, JW
    MELPOLDER, JC
    HOUGHTON, M
    CHOO, QL
    KUO, G
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) : 1494 - 1500
  • [2] THE NATURAL-HISTORY OF COMMUNITY-ACQUIRED HEPATITIS-C IN THE UNITED-STATES
    ALTER, MJ
    MARGOLIS, HS
    KRAWCZYNSKI, K
    JUDSON, FN
    MARES, A
    ALEXANDER, WJ
    HU, PY
    MILLER, JK
    GERBER, MA
    SAMPLINER, RE
    MEEKS, EL
    BEACH, MJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (27) : 1899 - 1905
  • [3] RISK-FACTORS FOR ACUTE NON-A, NON-B HEPATITIS IN THE UNITED-STATES AND ASSOCIATION WITH HEPATITIS-C VIRUS-INFECTION
    ALTER, MJ
    HADLER, SC
    JUDSON, FN
    MARES, A
    ALEXANDER, WJ
    HU, PY
    MILLER, JK
    MOYER, LA
    FIELDS, HA
    BRADLEY, DW
    MARGOLIS, HS
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 264 (17): : 2231 - 2235
  • [4] ISSUES IN SEARCHING MOLECULAR SEQUENCE DATABASES
    ALTSCHUL, SF
    BOGUSKI, MS
    GISH, W
    WOOTTON, JC
    [J]. NATURE GENETICS, 1994, 6 (02) : 119 - 129
  • [5] ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
  • [6] PCR-BASED CDNA LIBRARY CONSTRUCTION - GENERAL CDNA LIBRARIES AT THE LEVEL OF A FEW CELLS
    BELYAVSKY, A
    VINOGRADOVA, T
    RAJEWSKY, K
    [J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (08) : 2919 - 2932
  • [7] GENBANK
    BENSON, DA
    BOGUSKI, M
    LIPMAN, DJ
    OSTELL, J
    [J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (17) : 3441 - 3444
  • [8] CHOMCZYNSKI P, 1993, BIOTECHNIQUES, V15, P532
  • [9] DECKER RH, 1991, VIRAL HEPATITIS AND LIVER DISEASE, P795
  • [10] ISOLATION OF THE NOVEL AGENT FROM HUMAN STOOL SAMPLES THAT IS ASSOCIATED WITH SPORADIC NON-A, NON-B-HEPATITIS
    DEKA, N
    SHARMA, MD
    MUKERJEE, R
    [J]. JOURNAL OF VIROLOGY, 1994, 68 (12) : 7810 - 7815
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