Western Diet and the Immune System: An Inflammatory Connection

被引：556

作者：

Christ, Anette ^{[1
,2
]}

Lauterbach, Mario ^{[1
]}

Latz, Eicke ^{[1
,2
,3
,4
]}

机构：

[1] Univ Bonn, Univ Hosp Bonn, Inst Innate Immun, D-53127 Bonn, Germany

[2] UMass Med Sch, Dept Infect Dis & Immunol, Worcester, MA 01605 USA

[3] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, N-7491 Trondheim, Norway

[4] German Ctr Neurodegenerat Dis DZNE, D-53127 Bonn, Germany

来源：

IMMUNITY | 2019年 / 51卷 / 05期

关键词：

C-REACTIVE PROTEIN; CHAIN FATTY-ACIDS; TYPE-2; DIABETES-MELLITUS; NECROSIS-FACTOR-ALPHA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CARDIOVASCULAR RISK-FACTORS; FISH-OIL SUPPLEMENTATION; HISTONE DEACETYLASE 3; HEMATOPOIETIC STEM; INSULIN-RESISTANCE;

D O I：

10.1016/j.immuni.2019.09.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The consumption of Western-type calorically rich diets combined with chronic overnutrition and a sedentary lifestyle in Western societies evokes a state of chronic metabolic inflammation, termed metaflammation. Metaflammation contributes to the development of many prevalent non-communicable diseases (NCDs), and these lifestyle-associated pathologies represent a rising public health problem with global epidemic dimensions. A better understanding of how modern lifestyle and Western diet (WD) activate immune cells is essential for the development of efficient preventive and therapeutic strategies for common NCDs. Here, we review the current mechanistic understanding of how the Western lifestyle can induce metaflammation, and we discuss how this knowledge can be translated to protect the public from the health burden associated with their selected lifestyle.

引用

页码：794 / 811

页数：18

共 189 条

[71] Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages [J].

Ishiyama, Junichi ;

Taguchi, Ryoko ;

Akasaka, Yunike ;

Shibata, Saiko ;

Ito, Minoru ;

Nagasawa, Michiaki ;

Murakami, Koji .

JOURNAL OF LIPID RESEARCH, 2011, 52 (02) :299-307

[72] Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease [J].

Jaiswal, S. ;

Natarajan, P. ;

Silver, A. J. ;

Gibson, C. J. ;

Bick, A. G. ;

Shvartz, E. ;

McConkey, M. ;

Gupta, N. ;

Gabriel, S. ;

Ardissino, D. ;

Baber, U. ;

Mehran, R. ;

Fuster, V. ;

Danesh, J. ;

Frossard, P. ;

Saleheen, D. ;

Melander, O. ;

Sukhova, G. K. ;

Neuberg, D. ;

Libby, P. ;

Kathiresan, S. ;

Ebert, B. L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (02) :111-121

[73] Clonal Hematopoiesis and Atherosclerosis [J].

Cassinat, Bruno ;

Harrison, Claire ;

Kiladjian, Jean-Jacques .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (14) :1400-+

[74] DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men [J].

Kelley, Darshan S. ;

Siegel, David ;

Fedor, Dawn M. ;

Adkins, Yuriko ;

Mackey, Bruce E. .

JOURNAL OF NUTRITION, 2009, 139 (03) :495-501

[75] Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence [J].

Kerr, Jacqueline ;

Anderson, Cheryl ;

Lippman, Scott M. .

LANCET ONCOLOGY, 2017, 18 (08) :E457-E471

[76] Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial [J].

Kiecolt-Glaser, Janice K. ;

Belury, Martha A. ;

Andridge, Rebecca ;

Malarkey, William B. ;

Hwang, Beom Seuk ;

Glaser, Ronald .

BRAIN BEHAVIOR AND IMMUNITY, 2012, 26 (06) :988-995

[77] Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes [J].

Kien, C. Lawrence ;

Bunn, Janice Y. ;

Fukagawa, Naomi K. ;

Anathy, Vikas ;

Matthews, Dwight E. ;

Crain, Karen I. ;

Ebenstein, David B. ;

Tarleton, Emily K. ;

Pratley, Richard E. ;

Poynter, Matthew E. .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2015, 26 (12) :1599-1606

[78] Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice [J].

Kim, Myung H. ;

Kang, Seung G. ;

Park, Jeong H. ;

Yanagisawa, Masashi ;

Kim, Chang H. .

GASTROENTEROLOGY, 2013, 145 (02) :396-+

[79] L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans [J].

Koeth, Robert A. ;

Lam-Galvez, Betzabe Rachel ;

Kirsop, Jennifer ;

Wang, Zeneng ;

Levison, Bruce S. ;

Gu, Xiaodong ;

Copeland, Matthew F. ;

Bartlett, David ;

Cody, David B. ;

Dai, Hong J. ;

Culley, Miranda K. ;

Li, Xinmin S. ;

Fu, Xiaoming ;

Wu, Yuping ;

Li, Lin ;

DiDonato, Joseph A. ;

Tang, W. H. Wilson ;

Garcia-Garcia, Jose Carlos ;

Hazen, Stanley L. .

JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (01) :373-387

[80] Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis [J].

Koeth, Robert A. ;

Wang, Zeneng ;

Levison, Bruce S. ;

Buffa, Jennifer A. ;

Org, Elin ;

Sheehy, Brendan T. ;

Britt, Earl B. ;

Fu, Xiaoming ;

Wu, Yuping ;

Li, Lin ;

Smith, Jonathan D. ;

DiDonato, Joseph A. ;

Chen, Jun ;

Li, Hongzhe ;

Wu, Gary D. ;

Lewis, James D. ;

Warrier, Manya ;

Brown, J. Mark ;

Krauss, Ronald M. ;

Tang, W. H. Wilson ;

Bushman, Frederic D. ;

Lusis, Aldons J. ;

Hazen, Stanley L. .

NATURE MEDICINE, 2013, 19 (05) :576-585

← 3 4 5 6 7 8 9 10 11 12 →