Western Diet and the Immune System: An Inflammatory Connection

被引：554

作者：

Christ, Anette ^{[1
,2
]}

Lauterbach, Mario ^{[1
]}

Latz, Eicke ^{[1
,2
,3
,4
]}

机构：

[1] Univ Bonn, Univ Hosp Bonn, Inst Innate Immun, D-53127 Bonn, Germany

[2] UMass Med Sch, Dept Infect Dis & Immunol, Worcester, MA 01605 USA

[3] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, N-7491 Trondheim, Norway

[4] German Ctr Neurodegenerat Dis DZNE, D-53127 Bonn, Germany

来源：

IMMUNITY | 2019年 / 51卷 / 05期

关键词：

C-REACTIVE PROTEIN; CHAIN FATTY-ACIDS; TYPE-2; DIABETES-MELLITUS; NECROSIS-FACTOR-ALPHA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CARDIOVASCULAR RISK-FACTORS; FISH-OIL SUPPLEMENTATION; HISTONE DEACETYLASE 3; HEMATOPOIETIC STEM; INSULIN-RESISTANCE;

D O I：

10.1016/j.immuni.2019.09.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The consumption of Western-type calorically rich diets combined with chronic overnutrition and a sedentary lifestyle in Western societies evokes a state of chronic metabolic inflammation, termed metaflammation. Metaflammation contributes to the development of many prevalent non-communicable diseases (NCDs), and these lifestyle-associated pathologies represent a rising public health problem with global epidemic dimensions. A better understanding of how modern lifestyle and Western diet (WD) activate immune cells is essential for the development of efficient preventive and therapeutic strategies for common NCDs. Here, we review the current mechanistic understanding of how the Western lifestyle can induce metaflammation, and we discuss how this knowledge can be translated to protect the public from the health burden associated with their selected lifestyle.

引用

页码：794 / 811

页数：18

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