Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

被引：106
作者：
Berney, Daniel M. [1 ]
Looijenga, Leendert H. J. [2 ]
Idrees, Muhammad [3 ]
Oosterhuis, J. Wolter [2 ]
Rajpert-De Meyts, Ewa [4 ]
Ulbright, Thomas M. [3 ]
Skakkebaek, Niels E. [4 ]
机构：
[1] Queen Mary Univ London, St Bartholomews Hosp, Dept Mol Oncol, Barts Canc Inst, John Vane Bldg,Charterhouse Sq, London EC1M 6BQ, England
[2] Erasmus MC, Dept Pathol, Univ Med Ctr, Rotterdam, Netherlands
[3] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
[4] Univ Copenhagen, Dept Growth & Reprod, Rigshosp, Copenhagen, Denmark
来源：
HISTOPATHOLOGY | 2016年 / 69卷 / 01期
关键词：
carcinoma in situ; intratubular germ cell neoplasia; testicular intraepithelial neoplasia; testis; CARCINOMA INSITU; TESTIS; TUMORS; ORIGIN;
D O I：
10.1111/his.12958
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed carcinoma in situ' (CIS), it has also been known as intratubular germ cell neoplasia, unclassified' (IGCNU) and testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).
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页码：7 / 10
页数：4
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