The Physiology of Early Goal-Directed Therapy for Sepsis

被引：1

作者：

Lief, Lindsay ^{[1
]}

Arbo, John ^{[2
]}

Berlin, David A. ^{[1
]}

机构：

[1] Weill Cornell Med, Weill Dept Med, 1300 York Ave, New York, NY 10065 USA

[2] Weill Cornell Med, Div Emergency Med, New York, NY USA

来源：

JOURNAL OF INTENSIVE CARE MEDICINE | 2017年 / 32卷 / 10期

关键词：

sepsis; oxygen delivery; venous oxygen saturation; oxygen consumption; goal-directed therapy; PREDICT FLUID RESPONSIVENESS; VENOUS OXYGEN-SATURATION; BLOOD-CELL TRANSFUSION; HEMODYNAMIC THERAPY; SURVIVING SEPSIS; CLINICAL-TRIAL; SEPTIC SHOCK; DELIVERY; CONSUMPTION; PRESSURE;

D O I：

10.1177/0885066616671705

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In 2001, Rivers and colleagues published a randomized controlled trial of early goal-directed therapy (EGDT) for the treatment of sepsis. More than a decade later, it remains a landmark achievement. The study proved the benefits of early aggressive treatment of sepsis. However, many questions remain about specific aspects of the complex EGDT algorithm. Recently, 3 large trials attempted to replicate these results. None of the studies demonstrated a benefit of an EGDT protocol for sepsis. This review explores the physiologic basis of goal-directed therapy, including the hemodynamic targets and the therapeutic interventions. An understanding of the physiologic basis of EGDT helps reconcile the results of the clinical trials.

引用

页码：567 / 573

页数：7

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