Enantioselective synthesis of hyperparathyroidism agent Cinacalcet hydrochloride

被引：0

作者：

Ganesh, N. S. ^{[1
]}

Spandana, K. V. L. D. ^{[1
]}

Narsaiah, A. Venkat ^{[1
]}

机构：

[1] CSIR, Fluoro Agrochan Dept, Organ Synth Lab, Indian Inst Chem Technol, Hyderabad 500007, India

来源：

INDIAN JOURNAL OF CHEMISTRY | 2022年 / 61卷 / 05期

关键词：

Wittig reaction; CBS-reduction; oxidation; reductive amination; hyperparathyroidism; CALCIMIMETIC AGENT; ALDEHYDES; EFFICIENT; ALCOHOLS; ROUTE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient route has been developed for enantioselective synthesis of hyperparathyroidism agent (R)-Cinacalcet. The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive amination.

引用

页码：503 / 507

页数：5

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