Enantioselective synthesis of hyperparathyroidism agent Cinacalcet hydrochloride

被引：0
|
作者：
Ganesh, N. S. [1 ]
Spandana, K. V. L. D. [1 ]
Narsaiah, A. Venkat [1 ]
机构：
[1] CSIR, Fluoro Agrochan Dept, Organ Synth Lab, Indian Inst Chem Technol, Hyderabad 500007, India
来源：
INDIAN JOURNAL OF CHEMISTRY | 2022年 / 61卷 / 05期
关键词：
Wittig reaction; CBS-reduction; oxidation; reductive amination; hyperparathyroidism; CALCIMIMETIC AGENT; ALDEHYDES; EFFICIENT; ALCOHOLS; ROUTE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient route has been developed for enantioselective synthesis of hyperparathyroidism agent (R)-Cinacalcet. The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive amination.
引用
收藏
页码：503 / 507
页数：5
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