Bright lights down under: Metal ion complexes turning the spotlight on metabolic processes at the cellular level

被引：7
作者：
Gillam, Todd A. [1 ]
Sweetman, Martin J. [1 ,2 ,3 ]
Bader, Christie A. [4 ]
Morrison, Janna L. [5 ]
Hayball, John D. [2 ,3 ,6 ]
Brooks, Doug A. [4 ]
Plush, Sally E. [1 ,7 ]
机构：
[1] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA 5000, Australia
[2] Univ South Australia, Hanson Inst, Expt Therapeut Lab, Adelaide, SA 5000, Australia
[3] Univ South Australia, Sch Pharm & Med Sci, Sansom Inst, Adelaide, SA 5000, Australia
[4] Univ South Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Mech Cell Biol & Dis Res Grp, Adelaide, SA, Australia
[5] Univ South Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Early Origins Adult Hlth Res Grp, Adelaide, SA 5000, Australia
[6] Univ Adelaide, Sch Med, Discipline Obstet & Gynaecol, Robinson Res Inst, Adelaide, SA 5000, Australia
[7] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia
来源：
COORDINATION CHEMISTRY REVIEWS | 2018年 / 375卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
CARBONIC-ANHYDRASE-IX; ENDOPLASMIC-RETICULUM STRESS; CANCER-CELLS; IN-VITRO; IRIDIUM(III) COMPLEXES; RUTHENIUM COMPLEXES; SINGLET OXYGEN; POLYPYRIDINE COMPLEXES; LANTHANIDE COMPLEXES; IMAGING APPLICATIONS;
D O I：
10.1016/j.ccr.2017.11.026
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The widespread uptake and use of emissive metal ion complexes for investigating cellular structure, composition and function, is evidence of the effectiveness and vast potential for this type of imaging probe. Metal ion complexes provide significant advantages over their organic fluorophore counterparts, including long emission lifetime, resistance to photobleaching and the capacity to readily modify their peripheral chemistry to target specific organelles, signalling pathways and individual molecules. This review will discuss recent progress in the development and use of metal ion complexes, specifically for studying metabolic diseases at the cellular level. Advanced metal ion complexes for organelle imaging and the detection of biorelevant species, to elaborate complexes for understanding cellular mechanisms and recent therapeutic applications will be reviewed. To align with the special issue, Coordination Chemistry Reviews: Coordination Chemistry in Australia, the work of Australian researchers actively engaged in this field is featured prominently, along with key developments from the global research community. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：234 / 255
页数：22
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