Long Noncoding RNA Highly Upregulated in Liver Cancer Activates p53-p21 Pathway and Promotes Nasopharyngeal Carcinoma Cell Growth

被引：29

作者：

Jiang, Xue ^{[1
]}

Liu, Weiwei ^{[1
]}

机构：

[1] Hebei Med Univ, Cangzhou Cent Hosp, Dept Otolaryngol, Cangzhou 061001, Hebei, Peoples R China

来源：

DNA AND CELL BIOLOGY | 2017年 / 36卷 / 07期

关键词：

NPC; HULC; p53; p21; CYCLE PROGRESSION; CERVICAL-CANCER; HOTAIR PROMOTES; GASTRIC-CANCER; P21; EXPRESSION; OVARIAN-CANCER; PROLIFERATION; MALAT1; HULC; METASTASIS;

D O I：

10.1089/dna.2017.3686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dysfunction of lncRNA has been found in the nasopharyngeal carcinoma (NPC); however, the effect of lncRNA expression on NPC tumorigenesis as well as the molecular mechanism of lncRNA in the pathogenesis of NPC remain largely unknown. In this study, we showed that highly upregulated in liver cancer (HULC), the first identified lncRNA in hepatocellular carcinoma, is highly expressed in NPC patients and correlated with a poor prognosis of cancer patients. Overexpressed HULC promotes NPC cell growth. Downregulation of HULC activated p53 and induced the increased expression of p21, which finally caused cell cycle arrest and cell apoptosis. These results suggested that HULC acts as an oncogenic lncRNA in NPC and a potential therapeutic target in NPC treatment.

引用

页码：596 / 602

页数：7

共 35 条

[21] Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer [J].

Sun, X. ;

Du, P. ;

Yuan, W. ;

Du, Z. ;

Yu, M. ;

Yu, X. ;

Hu, T. .

CELL DEATH & DISEASE, 2015, 6 :e1907-e1907

[22]

Wu E, 2000, CLIN LAB MED, V20, P731

[23] Prognostic value of long non-coding RNA MALAT1 in cancer patients [J].

Wu, Yihua ;

Lu, Wei ;

Xu, Jinming ;

Shi, Yu ;

Zhang, Honghe ;

Xia, Dajing .

TUMOR BIOLOGY, 2016, 37 (01) :897-903

[24] LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells [J].

Xiong, H. ;

Ni, Z. ;

He, J. ;

Jiang, S. ;

Li, X. ;

He, J. ;

Gong, W. ;

Zheng, L. ;

Chen, S. ;

Li, B. ;

Zhang, N. ;

Lyu, X. ;

Huang, G. ;

Chen, B. ;

Zhang, Y. ;

He, F. .

ONCOGENE, 2017, 36 (25) :3528-3540

[25] Anticancer effects of 3,3′-diindolylmethane are associated with G1 arrest and mitochondria-dependent apoptosis in human nasopharyngeal carcinoma cells [J].

Xu, Yu ;

Zhang, Jin ;

Shi, Wendan ;

Liu, Yun .

ONCOLOGY LETTERS, 2013, 5 (02) :655-662

[26] High expression of long noncoding RNA HULC is a poor predictor of prognosis and regulates cell proliferation in glioma [J].

Yan, Hong ;

Tian, Rui ;

Zhang, Min ;

Wu, Jing ;

Ding, Min ;

He, Jie .

ONCOTARGETS AND THERAPY, 2017, 10 :113-120

[27] Genome-wide analysis of long non-coding RNA in primary nasopharyngeal carcinoma by microarray [J].

Yang, Qing-Qing ;

Deng, Yan-Fei .

HISTOPATHOLOGY, 2015, 66 (07) :1022-1030

[28]

Yang SP, 2015, DYNAMICS OF VEHICLE-ROAD COUPLED SYSTEM, P1, DOI 10.1007/978-3-662-45957-7_1

[29] Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer [J].

Yang, Xiao-Dong ;

Xu, Hong-Tao ;

Xu, Xiao-Hui ;

Ru, Gan ;

Liu, Wei ;

Zhu, Jun-Jia ;

Wu, Yong-You ;

Zhao, Kui ;

Wu, Yong ;

Xing, Chun-Gen ;

Zhang, Shu-Yu ;

Cao, Jian-Ping ;

Li, Ming .

ONCOLOGY REPORTS, 2016, 35 (01) :479-487

[30] Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway [J].

Ye, Le-chi ;

Chen, Tao ;

Zhu, De-xiang ;

Lv, Shi-xu ;

Qiu, Jun-jun ;

Xu, Jianmin ;

Yuan, Feng-lai ;

Wei, Ye .

ONCOTARGET, 2016, 7 (37) :58931-58938

← 1 2 3 4 →