Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs

被引：12
|
作者：
Singh, Erinprit K. [1 ]
Nazarova, Lidia A. [1 ]
Lapera, Stephanie A. [1 ]
Alexander, Leslie D. [1 ]
McAlpine, Shelli R. [1 ]
机构：
[1] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 33期
关键词：
CANCER; ALKYNES; DISEASE; DRUGS;
D O I：
10.1016/j.tetlet.2010.06.050
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity Published by Elsevier Ltd
引用
收藏
页码：4357 / 4360
页数：4
相关论文
共 50 条
  • [1] Synthesis and biological evaluation of cyclic tetrapeptides serving as histone deacetylase inhibitors
    Singh, Erinprit K.
    Lapera, Stephanie
    Nazarova, Lidia
    Vasko, Robert C.
    McAlpine, Shelli R.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [2] Cyclic tetrapeptides containing a zinc ligand as novel histone deacetylase inhibitors
    Jose, B
    Kato, T
    Sumida, Y
    Yoshida, M
    Nishino, N
    BIOPOLYMERS, 2003, 71 (03) : 396 - 396
  • [3] Cyclic tetrapeptides containing a zinc ligand as novel histone deacetylase inhibitors
    Jose, Binoy
    Kato, Tamaki
    Sumida, Yuko
    Yoshida, Minoru
    Nishino, Norikazu
    PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS, 2004, : 323 - 324
  • [4] Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand
    Nishino, N
    Yoshikawa, D
    Watanabe, LA
    Kato, T
    Jose, B
    Komatsu, Y
    Sumida, Y
    Yoshida, M
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (10) : 2427 - 2431
  • [5] Design, synthesis and evaluation of belinostat analogs as histone deacetylase inhibitors
    Zhang, Jie-Huan
    Mottamal, Madhusoodanan
    Jin, Hai-Shan
    Guo, Shanchun
    Gu, Yan
    Wang, Guangdi
    Zhao, Li-Ming
    FUTURE MEDICINAL CHEMISTRY, 2019, 11 (21) : 2765 - 2778
  • [6] Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic α3β-Tetrapeptides
    Olsen, Christian A.
    Ghadiri, M. Reza
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (23) : 7836 - 7846
  • [7] A modular approach to cyclic tetrapeptides related to histone deacetylase inhibition: synthesis of epi-microsporin A
    Mukherjee, Jyoti Prasad
    Sil, Suman
    Chattopadhyay, Shital K.
    TETRAHEDRON LETTERS, 2016, 57 (07) : 739 - 742
  • [8] Cyclic peptide histone deacetylase inhibitors
    Li Xiaohui
    Li Jianxun
    Li Shirong
    Xiu Zhilong
    Nishino Norikazu
    PROGRESS IN CHEMISTRY, 2007, 19 (05) : 762 - 768
  • [9] Mechanism in Inhibition of Histone Deacetylase by Cyclic Tetrapeptides with Various Functional Groups
    Nishino, N.
    Shahidul, I.
    Nurul, I.
    Nsiama, T.
    Oishi, N.
    Kato, T.
    Ito, A.
    Yoshida, M.
    JOURNAL OF PEPTIDE SCIENCE, 2010, 16 : 130 - 130
  • [10] Largazole analogs as selective histone deacetylase inhibitors
    Al-Hamashi, Ayad
    Almaliti, Jehad
    Farrell, Robert
    Tillekeratne, Viranga
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
12345