Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs

被引：12
作者：
Singh, Erinprit K. [1 ]
Nazarova, Lidia A. [1 ]
Lapera, Stephanie A. [1 ]
Alexander, Leslie D. [1 ]
McAlpine, Shelli R. [1 ]
机构：
[1] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 33期
关键词：
CANCER; ALKYNES; DISEASE; DRUGS;
D O I：
10.1016/j.tetlet.2010.06.050
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity Published by Elsevier Ltd
引用
收藏
页码：4357 / 4360
页数：4
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