Targeting the Proteasome With Bortezomib in Multiple Myeloma: Update on Therapeutic Benefit as an Upfront Single Agent, Induction Regimen for Stem-Cell Transplantation and as Maintenance Therapy

被引：8
作者：
Driscoll, James J. [1 ]
Burris, Jason [1 ,2 ]
Annunziata, Christina M. [1 ]
机构：
[1] NCI, Med Oncol Branch, Magnuson Canc Ctr, NIH,Translat Genom Sect, Bethesda, MD 20892 USA
[2] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA
来源：
AMERICAN JOURNAL OF THERAPEUTICS | 2012年 / 19卷 / 02期
关键词：
multiple myeloma; bortezomib; monotherapy; stem-cell transplantation induction; maintenance therapy; INCORPORATING BORTEZOMIB; NEDD8-ACTIVATING ENZYME; COMBINATION THERAPY; CLINICAL-OUTCOMES; PHASE-III; DEXAMETHASONE; TRIAL; EXPRESSION; LENALIDOMIDE; THALIDOMIDE;
D O I：
10.1097/MJT.0b013e3181ff7a9e
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bortezomib is the first therapeutic inhibitor of the proteasome that has demonstrated a significant clinical response in patients with otherwise refractory or rapidly advancing disease. Bortezomib has received US Federal Drug Administration approval for the treatment of the hematologic malignancies such as multiple myeloma and mantle cell lymphoma. Herein, the use of bortezomib as an upfront therapy, as an induction regimen before stem-cell transplantation and as maintenance therapy in the treatment of multiple myeloma is discussed.
引用
收藏
页码：133 / 144
页数：12
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