Extramedullary plasmacytoma of the salivary gland in two Syrian hamsters (Mesocricetus auratus)

被引：6

作者：

Munday, JS ^{[1
]}

Richey, LJ ^{[1
]}

Brown, CA ^{[1
]}

Rodriguez, NA ^{[1
]}

Kiupel, M ^{[1
]}

机构：

[1] Massey Univ, Inst Vet Anim & Biomed Sci, Palmerston North, New Zealand

来源：

VETERINARY PATHOLOGY | 2005年 / 42卷 / 06期

关键词：

B-lymphocyte; hamsters; plasmacytoma; salivary neoplasia;

D O I：

10.1354/vp.42-6-819

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Two Syrian hamsters developed marked swelling of the ventral neck. Histologic examination of both masses revealed that the submaxillary salivary glands were effaced by large numbers of neoplastic plasma cells. In one hamster, neoplastic cells had infiltrated the adjacent lymph node. The neoplastic cells expressed CD79a antigen and were negative for CD3, lambda.. and kappa light chains. Ultrastructural features of neoplastic cells in the salivary gland of one hamster included abundant cytoplasmic rough endoplasmic reticulum profiles, and peripherally displaced nuclei that contained marginated heterochromatin, consistent with plasma cells. Salivary gland plasmacytomas are extremely rare in humans and have not previously been reported in nonhuman species. The occurrence of such neoplasms in two hamsters suggests that this species may be predisposed to developing tumors of this type.

引用

页码：819 / 823

页数：5