Ternary copper(II) complex of 1,10-phenanthroline and L-glycine: crystal structure and interaction with DNA

被引：53
|
作者：
Zhang, Shouchun [1 ]
Zhou, Jianliang [1 ]
机构：
[1] Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2008年 / 61卷 / 15期
关键词：
copper complex; DNA binding; DNA cleavage; 1,10-phenanthroline; L-glycine;
D O I：
10.1080/00958970801932605
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A ternary copper(II) complex, [Cu(phen)(L-Gly)(H(2)O)] center dot NO(3) center dot 1.5H(2)O (phen =1,10-phenanthroline, L-Gly =L-glycine), has been synthesized and structurally characterized. The complex crystallized in a monoclinic system with space group C2/c, a = 20.572(3) angstrom, b = 6.9987(10) angstrom, c = 23.561(3) angstrom, beta = 98.776(5)degrees. The five-coordinate copper(II) center is a distorted square pyramid. Absorption spectra, fluorescence spectra and viscosity measurements showed interaction between the copper complex and DNA through an intercalative mode. The complex exhibited efficient DNA cleavage activity at micromolar concentration in the presence of ascorbate with hydroxyl radicals as the active species.
引用
收藏
页码：2488 / 2498
页数：11
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