Ternary copper(II) complex of 1,10-phenanthroline and L-glycine: crystal structure and interaction with DNA

被引：53
|
作者：
Zhang, Shouchun [1 ]
Zhou, Jianliang [1 ]
机构：
[1] Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2008年 / 61卷 / 15期
关键词：
copper complex; DNA binding; DNA cleavage; 1,10-phenanthroline; L-glycine;
D O I：
10.1080/00958970801932605
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A ternary copper(II) complex, [Cu(phen)(L-Gly)(H(2)O)] center dot NO(3) center dot 1.5H(2)O (phen =1,10-phenanthroline, L-Gly =L-glycine), has been synthesized and structurally characterized. The complex crystallized in a monoclinic system with space group C2/c, a = 20.572(3) angstrom, b = 6.9987(10) angstrom, c = 23.561(3) angstrom, beta = 98.776(5)degrees. The five-coordinate copper(II) center is a distorted square pyramid. Absorption spectra, fluorescence spectra and viscosity measurements showed interaction between the copper complex and DNA through an intercalative mode. The complex exhibited efficient DNA cleavage activity at micromolar concentration in the presence of ascorbate with hydroxyl radicals as the active species.
引用
收藏
页码：2488 / 2498
页数：11
相关论文
共 50 条
  • [1] Synthesis, Characterization, Crystal Structure and Interaction with DNA of Copper(II) Complex with Undecylenic Acid and 1,10-Phenanthroline
    Xian Hui-Duo
    Liu Jian-Feng
    Zhao Guo-Liang
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2009, 25 (11) : 2066 - 2069
  • [2] Synthesis, Crystal Structure and DNA Interaction of a Copper(II) Complex with Ligands of L-Phenylalanine Schiff Base and 1,10-Phenanthroline
    Pu Xuewei
    Li Lianzhi
    Dong Jianfang
    Huang Lei
    Bian Lin
    ACTA CHIMICA SINICA, 2011, 69 (06) : 647 - 652
  • [3] BIS(1,10-PHENANTHROLINE)COPPER(II) COMPLEXES - REFINEMENT OF THE CRYSTAL-STRUCTURE OF THE DITHIOCYANATO-BIS(1,10-PHENANTHROLINE)COPPER(II) COMPLEX
    KABESOVA, M
    KOZISKOVA, Z
    COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1992, 57 (06) : 1269 - 1277
  • [4] Synthesis, characterization and crystal structure of ternary cu(II) complex with 1,10-phenanthroline and L-methioninate
    Le, XY
    Tong, ML
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2002, 18 (10) : 1023 - 1027
  • [5] Synthesis, characterization and crystal structure of a ternary Cu(II) complex with 1,10-phenanthroline and L-leucinate
    Le, XY
    Zhou, XH
    Huang, CJ
    Feng, XL
    JOURNAL OF COORDINATION CHEMISTRY, 2003, 56 (10) : 861 - 867
  • [6] Synthesis and Crystal Structure of a Copper(II) Complex with Benzilic Acid and 1,10-Phenanthroline
    谢和平
    王颖
    李玉林
    Chinese Journal of Structural Chemistry, 2008, (07) : 801 - 804
  • [7] Synthesis and crystal structure of a copper(II) complex with benzilic acid and 1,10-phenanthroline
    Xie He-Ping
    Wang Ying
    Li Yu-Lin
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2008, 27 (07) : 801 - 804
  • [8] Synthesis, characterization, and crystal structure of a copper(II) complex of 1,10-phenanthroline and succinate
    Shad, Hazoor A.
    Thebo, Khalid H.
    Ibupoto, Zafar H.
    Malik, Muhammad A.
    O'Brien, Paul
    Raftery, James
    JOURNAL OF COORDINATION CHEMISTRY, 2011, 64 (13) : 2353 - 2360
  • [9] Synthesis and Crystal Structure of a Copper(II) Complex with Benzilic Acid and 1,10-Phenanthroline
    谢和平
    王颖
    李玉林
    结构化学, 2008, (07) : 801 - 804
  • [10] Synthesis and crystal structure of a binuclear fumarate complex of copper(II) with 1,10-phenanthroline
    Li, ZY
    Xu, DJ
    Wu, JY
    Chiang, MY
    JOURNAL OF COORDINATION CHEMISTRY, 2002, 55 (12) : 1397 - 1400
12345