TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

被引：7

作者：

van Meeteren, Laurens A. ^{[1
]}

Goumans, Marie-Jose

ten Dijke, Peter

机构：

[1] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RC Leiden, Netherlands

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2011年 / 12卷 / 12期

关键词：

ALK1; angiogenesis; BMP; cancer; Endoglin; Smad; TGF-beta; anti-angiogenesis therapy; HEREDITARY HEMORRHAGIC TELANGIECTASIA; BONE MORPHOGENETIC PROTEIN; VASCULAR SMOOTH-MUSCLE; HUMAN SOLID TUMORS; ENDOTHELIAL-CELL PROLIFERATION; CD105; MONOCLONAL-ANTIBODIES; ENDOGLIN EXPRESSION; PULMONARY-HYPERTENSION; BREAST-CARCINOMA; SOLUBLE ENDOGLIN;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiogenesis, the formation of new blood vessels is essential for diverse physiological processes such as development, but also for pathological conditions like tumor growth. Most studied in this context are tyrosine kinase signaling pathways such as those involving vascular endothelial growth factor (VEGF). There is however accumulating evidence that more pathways are as essential for angiogenesis. Knockout studies of factors in transforming growth factor (TGF-beta) signaling have for example showed that also this pathway is indispensable for angiogenesis. This review highlights our understanding of TGF-beta signaling in vascular development and angiogenesis. In particular, we focus on recent insights into the role of the TGF-beta type I receptor ALK1 and co-receptor endoglin in tumor angiogenesis, which provide opportunities for the development of new anti-angiogenesis therapies for treatment of cancer patients.

引用

页码：2108 / 2120

页数：13

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