The role of Toll-like receptors in health and disease - short review

被引：0
作者：
Dabrowska, Aleksandra [1 ]
Slotwinski, Robert [1 ,2 ]
Kedziora, Sylwia [1 ]
机构：
[1] Med Univ Warsaw, Dept Immunol & Nutr, PL-02106 Warsaw, Poland
[2] Polish Acad Sci, Med Res Ctr, Dept Surg Res & Transplantol, Warsaw, Poland
来源：
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY | 2012年 / 37卷 / 01期
关键词：
Toll-like receptors (TLRs); innate immunity; RHEUMATOID-ARTHRITIS; NEGATIVE REGULATOR; MYD88; DEFICIENCY; DOWN-REGULATION; EXPRESSION; INFLAMMATION; CELLS; TLR4; MONOCYTES; LIGANDS;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) are a group of proteins involved in recognition of highly conserved microbial structures and endogenous molecules released during tissue damage, which makes them key players in innate immunity. By activating nuclear factor kappa B (NF kappa B), TLRs are also involved in several physiological processes including angiogenesis, apoptosis, and tissue repair As shown in recent publications, disorder of TLRs signaling pathways as well as abnormalities in their expression may underlie various diseases, such as sepsis, life-threatening infections, tumors. This paper reviews the role of TLRs in innate immune response and consequences of disturbances in their functioning.
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页码：85 / 89
页数：5
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