SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SEVERAL BIS-QUATERNIZED AMMONIUM DERIVATIVES OF THE DITERPENOID ISOSTEVIOL

被引：10

作者：

Korochkina, M. G. ^{[1
]}

Babaev, V. M. ^{[1
]}

Strobykina, I. Yu. ^{[1
]}

Voloshina, A. D. ^{[1
]}

Kulik, N. V. ^{[1
]}

Kataev, V. E. ^{[1
]}

机构：

[1] Russian Acad Sci, Kazan Sci Ctr, AE Arbuzov Organ & Phys Chem Inst, Kazan 420088, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2012年 / 47卷 / 06期

关键词：

terpenoids; isosteviol; ammonium compounds; antimicrobial activity;

D O I：

10.1007/s10600-012-0103-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Previously unreported bis-quaternized ammonium derivatives of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) were synthesized. The compound in which the two quaternized N atoms were joined by a dodecamethylene spacer had the greatest antimicrobial activity and was comparable in activity with ciprofloxacin and clotrimazole.

引用

页码：914 / 917

页数：4

共 9 条

[1] Cationic Surfactants Derived from Lysine: Effects of Their Structure and Charge Type on Antimicrobial and Hemolytic Activities [J].

Colomer, A. ;

Pinazo, A. ;

Manresa, M. A. ;

Vinardell, M. P. ;

Mitjans, M. ;

Infante, M. R. ;

Perez, L. .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (04) :989-1002

[2] Synthesis and neuromuscular blocking activity of 16β-N-methylpiperazino steroidal derivatives [J].

Jindal, DP ;

Piplani, P ;

Fajrak, H ;

Prior, C ;

Marshall, IG .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (11) :901-908

[3]

KHAIBULLIN RN, 2009, ZH OBSHCH KHIM, V79, P795

[4]

Korochkina M. G., 2010, KHIM FARM ZH, V44, P10

[5]

Milovanova S. N., 1971, METHODS EXPT CHEM, P100

[6]

MILOVANOVA SN, 1971, METODY EKSPERIMENTAL, P318

[7]

PATON WDM, 1952, PHARMACOL REV, V4, P219

[8]

VEDMINA EA, 1964, HDB MICROBIOLOGY CLI, V1, P670

[9]

Zana R., 2003, Gemini Surfactants: Synthesis, Interfacial and Solution-Phase Behavior, and Applications

← 1 →